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Medicament composition for treating chronic otitis media and preparation method thereof

A technology of chronic otitis media and composition, applied in the field of pharmaceutical composition for treating chronic otitis media and its preparation, which can solve the problems of high price, poor curative effect, difficulty for ordinary patients, etc., and achieve simple preparation method, good economic significance and social significance , the effect of alleviating clinical symptoms

Inactive Publication Date: 2015-03-04
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xiyin is clinically divided into simple, bone ulcer type and cholesteatoma type. The latter two types require surgical treatment. Bacterial strains often relapse after stopping the drug due to colds, fatigue, emotional changes and other incentives, so the curative effect is not good, causing great pain to patients
In addition, most of the ear drops in the market are expensive, and it is difficult for ordinary patients to bear

Method used

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  • Medicament composition for treating chronic otitis media and preparation method thereof

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Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Rhododendron extract

[0013] Weigh 1.30 kg of dry red pair knots, crush it into granules, put it in an extraction device with a round bottom flask, add 12 L of purified water to reflux for extraction for 2 hours, filter, discard the filtrate, repeat 2 times, the obtained filter residue is added without 10L of water and ethanol was extracted under reflux for 2 hours, filtered, and repeated twice. The filtrates were combined, concentrated under reduced pressure to form a thick paste, freeze-dried, crushed into fine powder, and passed through a 100-mesh sieve to obtain the dry powder of the ethanol extract of Rhizoma chinensis. When in use, the dry powder of the extract is dissolved in 75% alcohol, prepared into a solution with a concentration of 20 mg / mL, and administered as ear drops.

Embodiment 2

[0014] The preparation of embodiment 2 Rhododendron extract

[0015] Weigh 1.05 kg of dry red pair knots, crush it into granules, place it in an extraction device with a round bottom flask, add 10 L of purified water to reflux for extraction for 1.5 h, filter, discard the filtrate, repeat 2 times, and the obtained filter residue is added Reflux extraction with 10 L of absolute ethanol for 2 hours, filter, repeat twice, combine the filtrates, concentrate under reduced pressure to form a thick paste, freeze-dry, pulverize into fine powder, and pass through a 100-mesh sieve to obtain the dry powder of the extract of Rhizoma chinensis.

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Abstract

The invention discloses a medicament composition for treating chronic otitis media and a preparation method thereof. The medicament composition is prepared from active components and additives, wherein the active components are ethanol extracts of ovate-leaved viburnum root. The preparation method of the medicament composition comprises the following steps: adding water into an ovate-leaved viburnum root raw material for extraction, filtering, removing a filtrate, adding absolute ethyl alcohol into obtained filter residues for reflux extraction, filtering, performing reduced pressure concentration on the filtrate, drying to obtain the ethanol extracts of ovate-leaved viburnum root, and uniformly mixing with the additives to prepare the medicament composition. By adopting the ethanol extracts of ovate-leaved viburnum root, disclosed by the invention, purulent secretions of auditory canals of patients can be removed, external auditory canals can be dried, and diseases of the patients cannot relapse for more than half a year, so that the ethanol extracts of ovate-leaved viburnum root are suitable for being prepared into ear drops for treating chronic suppurative otitis media.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a pharmaceutical composition for treating chronic otitis media and a preparation method thereof. Background technique [0002] Chronic otitis media is a relatively common disease in otolaryngology. The inflammation of the nasopharynx invades the middle ear through the eustachian tube repeatedly, and the clinical manifestations are otalgia, otorrhea, perforation of the tympanic membrane, and hearing loss. Chronic suppurative otitis media is a common disease with a long course of disease, affecting hearing, and even threatening life. Xiyin is clinically divided into simple, bone ulcer type and cholesteatoma type. The latter two types require surgical treatment. Bacterial strains often show recurrent attacks due to incentives such as colds, excessive fatigue, and emotional changes after drug withdrawal, so the curative effect is not good ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P27/16
CPCA61K36/35A61K9/0046A61K9/08A61K2236/33A61K2236/331
Inventor 徐嬉平巩霞王佳何世英
Owner QINGDAO MUNICIPAL HOSPITAL
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