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Preparation method of curcumin flexible liposome cream

A flexible liposome and curcumin technology, applied in the chemical field, can solve the problems of low liposome concentration, time-consuming, unfavorable encapsulation of hydrophobic drugs, etc., to improve cosmetic effects, large space and development prospects, and improve drug efficacy and the effect of cosmetic antioxidant function

Inactive Publication Date: 2015-03-25
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the prepared liposome has a low concentration, which is not conducive to the encapsulation of hydrophobic drugs. At the same time, a small amount of surfactant may remain, which is time-consuming

Method used

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  • Preparation method of curcumin flexible liposome cream
  • Preparation method of curcumin flexible liposome cream
  • Preparation method of curcumin flexible liposome cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0060] The principles and features of the present invention are described below, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0061] 1 Experimental Instruments and Reagents

[0062] 1.1 Instrument

[0063]

[0064]

[0065] 1.2 Reagents and preparation

[0066]

[0067]

[0068] 1.2.1 Preparation of reagents

[0069] Preparation of phosphate buffer solution (pH=7.0): Take 1.09 g of disodium phosphine hydrogen dodecanoate and 0.23 g of sodium dihydrogen phosphate dihydrate in a 100 ml volumetric flask, dissolve in deionized water, shake well, and set to volume. have to.

[0070] 2 Establishment of the experimental method

[0071] 2.1 Determination of curcumin content in liposomes

[0072] From the structural formula of curcumin, it can be seen that there is a conjugated structure in its molecule, so this experiment uses ultraviolet spectrophotometry to detect the conte...

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Abstract

The invention relates to a preparation method of a curcumin flexible liposome cream. The preparation method comprises the following three steps: preparing a curcumin flexible liposome, preparing freeze-dried powder from the curcumin flexible liposome, and preparing a curcumin flexible liposome cream. According to the preparation method disclosed by the invention, a curcumin liposome and a flexible liposome are prepared by virtue of a thin film dispersion process, and emulsible pastes of the curcumin liposome and the flexible liposome are prepared by virtue of an emulsification process so as to ensure that an optimal prescription is screened out and is subjected to stability evaluation and sensory evaluation, the utilization degree of curcumin can be improved, the emulsible pastes can be finer and more lubricant, and more choices can be provided in the application of cosmeceuticals in the future.

Description

technical field [0001] The invention relates to a preparation method of curcumin flexible liposome cream, which belongs to the field of chemistry. Background technique [0002] 1 Properties and functions of curcumin [0003] Curcumin is a yellow pigment extracted from the rhizomes of plants such as ginger. It is a polyphenolic substance with a small relative molecular weight, and it is generally considered to be the most effective ingredient in turmeric. Its structure is as follows: figure 1 shown. Physical properties: orange-yellow powder, slightly bitter taste, melting point 183°. Insoluble in water and ether, soluble in ethanol and propylene glycol, easily soluble in glacial acetic acid and alkali solution, reddish-brown in alkaline, yellow in neutral and acidic. It has strong stability to reducing agents and has coloring properties, but it is not sensitive to light and heat. Sensitive to iron ions. [0004] Curcumin has anti-inflammatory, anti-oxidation, anti-cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A61Q19/08
Inventor 陈大全
Owner YANTAI UNIV
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