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Preparation method of medicament for perfusion treatment of malignant pleural effusion

A malignant pleural effusion and drug technology, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of reducing the recurrence rate, increasing the recurrence rate of pleural effusion, and high recurrence rate, so as to alleviate pleural irritation pain, The effect of reducing the incidence of pleural reaction and accelerating blood circulation

Inactive Publication Date: 2015-04-29
孟芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are two main perfusion fluids for hyperthermic pleural perfusion therapy: one is normal saline, which has poor timeliness in controlling pleural effusion and has a high recurrence rate; the other is chemotherapy drugs, such as cisplatin and nedaplatin, whose mechanism of action lies in the local Anti-cancer and promotion of pleural adhesions, but clinically, due to excessive adhesion promotion, a large amount of cellulose is deposited on the pleura, capillaries and fibroblasts in the pleura grow into the cellulose, become granulation tissue, and become thicker The dense, dense capsule forms an organized pleural fibrous plate, which wraps the lung tissue extensively and hard, lacks elasticity, restricts thoracic activity, severely reduces respiratory function, and increases the recurrence of pleural effusion.
[0005] Therefore, there is still a lack of clinically effective pleural perfusion fluid that can effectively improve respiratory function and reduce the recurrence rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1, raw material drug weight ratio: 2 parts of crab seven, 8 parts of longum, 16 parts of Jiaobei, 16 parts of sweet clover, 6 parts of Eupatorium, 16 parts of Kuhulu, 16 parts of Ulva, 6 parts of red stone fat , 16 parts of cicada slough, 16 parts of sand ginger, 6 parts of mussels, and 2 parts of needle sand.

[0037] The preparation method of embodiment 1 is:

[0038](1) The above-mentioned raw materials are screened to remove impurities, measured, mixed, and pulverized, and then put into the percolation kettle, add twice the weight of raw materials and ethanol with a volume concentration of 98%, heat to 80°C, and carry out percolation after heating for 6 hours;

[0039] (2) Inject the leachate obtained in step 1 into the distillation kettle to concentrate, return the distillate to the percolation kettle to continue diafiltration, control the filtration rate to 100 ml / min kg, and circulate the diafiltration extraction until the color of the filtrate does not c...

Embodiment 2

[0044] Example 2, the weight ratio of raw materials: 1 part of crab seven, 6 parts of longan longan, 20 parts of Jiaobei, 12 parts of sweet clover, 12 parts of eupatorium, 20 parts of Kuhulu, 10 parts of Ulva, 3 parts of red stone fat , 12 parts of cicada slough, 12 parts of sand ginger, 3 parts of mussels, and 1 part of needle sand.

Embodiment 3

[0045] Example 3, the weight ratio of raw materials: 3 parts of crab seven, 9 parts of longum, 12 parts of Jiaobei, 20 parts of sweet clover, 3 parts of Eupatorium, 12 parts of Kuhulu, 25 parts of Ulva, 12 parts of red stone fat , 20 parts of cicada slough, 20 parts of sand ginger, 12 parts of mussels, and 5 parts of needle sand.

[0046] The Chinese medicine of embodiment 2,3 can be prepared by the following method:

[0047] (1) Extract the volatile oil from the coarse powder of Eupatorium, Piper longum, Cicada slough, Sha Jiang, and Melilotus osmanthus respectively, and collect them and mix them for later use, and the dregs for later use;

[0048] (2) Soak the needle sand in water at 40°C, filter it after 48 hours, and use the filtrate for later use;

[0049] (3) Mix Kuhulu, Jiaobei, Chishizhi, Crab Seven, Ulva, mussels and the dregs of the medicine in step 1, add the filtrate in step 2, decoct twice, 1 hour each time, combine and decoct liquid, stand and filter, and obtai...

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Abstract

The invention discloses a preparation method of a medicament for perfusion treatment of malignant pleural effusion for solving the treatment problem of malignant pleural effusion. Clinical experiments prove that the medicament has the characteristics of good curative effect and relatively high safety in treatment of malignant pleural effusion and is worthy of clinical application and popularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a medicine for perfusion treatment of malignant pleural effusion. Background technique [0002] Malignant pleural effusion (MPE) is one of the common complications in patients with advanced tumors. Patients often have different clinical manifestations such as progressive dyspnea, cough and chest pain, which not only seriously affect the quality of life of patients, but also often lead to poor survival. shortened lifespan and increased mortality. [0003] Traditional treatment methods for malignant pleural effusion include surgical pleural stripping, intrathoracic chemotherapy, pleural adhesion drug injection, etc., but the overall treatment effect is unsatisfactory, with many complications and severe side effects. In recent years, hyperthermic pleural perfusion therapy has provided a new idea and theoretical technical support for the treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P7/10A61P11/00A61P35/00A61K35/64A61K33/26A61K35/618
Inventor 孟芹
Owner 孟芹
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