Preparation method of intrapleural hyperthermal infusion fluid

A technology of heat perfusion and thoracic cavity, applied in the direction of medical preparations containing active ingredients, blood diseases, pharmaceutical formulas, etc., can solve the problems of reducing recurrence rate, limited thoracic activity, poor timeliness, etc., to relieve pleural irritation pain, Effect of reducing platelet aggregation rate and aggregation speed

Inactive Publication Date: 2015-06-03
阮秀云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two main perfusion fluids for hyperthermic pleural perfusion therapy: one is normal saline, which has poor timeliness in controlling pleural effusion and has a high recurrence rate; the other is chemotherapy drugs, such as cisplatin and nedaplatin, whose mechanism of action lies in the local Anti-cancer and promotion of pleural adhesions, but clinically, due to excessive adhesion promotion, a large amount of cellulose is deposited on the pleura, capillaries and fibroblasts in the pleura grow into the cellulose, become granulation tissue, and become thicker The dense, dense capsule forms an organized pleural fibrous plate, which wraps the lung tissue extensively and hard, lacks elasticity, restricts thoracic activity, severely reduces respiratory function, and increases the recurrence of pleural effusion.
[0004] Therefore, there is still a lack of clinically effective pleural perfusion fluid that can effectively improve respiratory function and reduce the recurrence rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1, the weight ratio of raw materials: 2 parts of crab seven, 8 parts of longan longan, 2 parts of water safflower seeds, 16 parts of eucalyptus leaves, 16 parts of sea sinensis, 6 parts of fruit upper leaves, 6 parts of fragrant osmanthus, 16 parts of ginger, 16 parts of cicadas, 6 parts of mussels.

[0035] The preparation method of embodiment 1 is:

[0036] (1) The above-mentioned raw materials are screened to remove impurities, measured, mixed, and pulverized, and then put into the percolation kettle, add 3 times the weight of the raw materials and ethanol with a volume concentration of 98%, heat to 60°C, and carry out percolation after heating for 5 hours;

[0037] (2) Pour the leachate obtained in step 1 into the distillation kettle to concentrate, return the distillate to the percolation kettle to continue diafiltration, control the filtration rate to 120 ml / min kg, and circulate the diafiltration extraction until the color of the filtrate does not change ...

Embodiment 2

[0042] Example 2, the weight ratio of raw materials: 1 part of crab seven, 6 parts of longan longan, 1 part of water safflower seed, 20 parts of eucalyptus leaves, 10 parts of sea sinensis, 12 parts of upper leaves of fruit, 12 parts of sand ginger, fragrance 3 parts of osmanthus, 12 parts of cicadas, 3 parts of mussels.

Embodiment 3

[0043] Example 3, the weight ratio of raw materials: 3 parts of crab seven, 9 parts of longan longan, 5 parts of water safflower seeds, 12 parts of eucalyptus leaves, 25 parts of sea sinensis, 3 parts of fruit upper leaves, 20 parts of sand ginger, fragrance 12 parts of osmanthus, 20 parts of cicadas, 12 parts of mussels, 20 parts of sweet clover, 12 parts of fennel.

[0044] The Chinese medicine of embodiment 2,3 can be prepared by the following method:

[0045] (1) Extract the volatile oils from the coarse powder of Piper longum longum, Chickweed, eucalyptus leaves, Qingxianggui, cicada slough, Shuihonghuazi, sand ginger, and sweet-scented clover, and collect them and mix them for later use, and the dregs for later use;

[0046] (2) Mix the fruit leaves, crab seven, sea sage, mussels and the dregs of the medicine in step 1, add 3 times the amount of water, decoct 2 times, 1 hour each time, combine the decoction, let stand and filter After that, the filtrate is used for subs...

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Abstract

The invention discloses a preparation method of intrapleural hyperthermal infusion fluid. The preparation method is characterized in that the intrapleural hyperthermal infusion fluid is prepared from the following raw material medicines: root and rhizome of Japanese false solomonseal, leaf of tasmanian bluegum, herb of denseflower bulbophyllum, mussel, fragrant sarcococca herb, cicada slough, motherwort fruit, sweet clover, kacmpferia galangal, princes-feather fruit and alga sgrgassi enerves. Proven by clinical experiments, the intrapleural hyperthermal infusion fluid disclosed by the invention has the characteristics of good curative effects and relatively high safety, and is worthy of being clinically applied and popularized.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing thoracic perfusion fluid. Background technique [0002] Hyperthermic perfusion therapy is a new therapy for tumors treated by hyperthermia. Its principle is to use physical energy to heat the liquid and infuse it into the tumor site, so that the temperature of the tumor tissue rises to the effective treatment temperature and maintains it for a certain period of time. The difference in temperature tolerance can achieve the therapeutic purpose of making tumor cells apoptosis without damaging normal tissues. [0003] For tumor patients who have already developed cancerous pleural effusion, the pleural cavity is filled with fluid. It is a new idea and theory in recent years to perform hyperthermic pleural perfusion therapy while draining pleural effusion. At present, there are two main perfusion fluids for hyperthermic pleural perfusion therapy: on...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61P7/10A61P11/00A61K35/618A61K35/64
Inventor 阮秀云王蓉华孟琴
Owner 阮秀云
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