Chicken matrix reference material containing amantadine and ribavirin and preparation method of chicken matrix reference material

A kind of technology of amantadine and standard substance, which is applied in the field of chicken matrix standard substance containing amantadine and ribavirin and preparation thereof

Inactive Publication Date: 2015-05-06
INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the existing quality control methods for residue analysis mostly adopt the form of matrix addition, which has defects such as large matrix differences and different binding states of target compounds. It mainly exists in the form of original drug, monophosphate, diphosphate and triphosphate, which makes it more difficult to control the analytical quality of such compounds

Method used

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  • Chicken matrix reference material containing amantadine and ribavirin and preparation method of chicken matrix reference material
  • Chicken matrix reference material containing amantadine and ribavirin and preparation method of chicken matrix reference material
  • Chicken matrix reference material containing amantadine and ribavirin and preparation method of chicken matrix reference material

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Embodiment 1

[0024] A kind of preparation method of chicken matrix standard substance containing amantadine and ribavirin:

[0025] （1） Amantadine and ribavirin were administered orally in multiple doses, and 200 white-feathered broilers with a body weight of about 1 kg were selected. Each dose was ribavirin 6g / 100kg water, amantadine 3g / 100kg water, each Dosing once a day, continuous administration for 4 days, taking samples on the 3rd day after drug withdrawal, so that amantadine and ribavirin drugs can be metabolized in broiler chickens, and their metabolic curves are measured to obtain amantadine and ribavirin in muscle. For live chickens with a concentration of bavirin of 7-13 μg / kg, the broiler chickens are slaughtered, hair removed, skin and bones removed, and the front breast meat is taken to obtain chicken meat containing amantadine and ribavirin;

[0026] (2) Take the broiler chickens that have been raised according to the specified feeding time in step (1), slaughter them, remo...

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Abstract

The invention discloses a chicken matrix reference material containing amantadine and ribavirin and a preparation method of the chicken matrix reference material, wherein the preparation method comprises the following steps: feeding live white feather broilers with water containing amantadine and ribavirin, slaughtering the live broilers after amantadine and ribavirin are metabolized to a proper concentration in the live broilers, taking the brisket end, and obtaining the matrix reference material after homogenization and sterilization. According to the invention, the chicken matrix reference material is a natural pollution reference sample, the reference sample can be used for the quality control of relevant detection and analysis, and the sample is homogeneous, stable, convenient to transport and reliable to use.

Description

technical field [0001] The invention belongs to the technical field of animal-derived food matrix standard substances for detection of veterinary drug residues, and more specifically relates to a chicken matrix standard substance containing amantadine and ribavirin and a preparation method thereof. Background technique [0002] Amantadine is also known as amantadine and tricyclodecanylamine, CAS number: 768-94-5, molecular weight: 151.2487. The chemical name of Ribavirin is: 1-B-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide, also known as ribavirin and ribavirin. [0003] Both amantadine and ribavirin are the main antiviral drugs for human use. At present, there are no antiviral drugs specifically for animal viruses. Most of the drugs on the market are antiviral drugs for humans and transplanted for animals. There are problems such as drug resistance and residues in transplanted veterinary drugs. Many countries have banned the use of antiviral drugs to prevent and treat v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N30/06G01N30/02
Inventor 刘正才杨方吕小玲
Owner INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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