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Method for determining active ingredients with myocardial protection and anti-inflammatory action in traditional Chinese medicine

An active ingredient, myocardial protection technology, applied in the field of traditional Chinese medicine, can solve the problems of complex chemical composition, unclear chemical composition and active ingredients, affecting the clinical efficacy of traditional Chinese medicine, etc., to ensure clinical efficacy and achieve the effect of quality control

Active Publication Date: 2015-07-15
津药达仁堂集团股份有限公司乐仁堂制药厂 +1
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Problems solved by technology

However, due to the complex chemical components of traditional Chinese medicine, it is not clear which chemical components in each traditional Chinese medicine are the active ingredients with cardioprotective and anti-inflammatory effects, and the content of these active ingredients cannot be determined, which is not conducive to the quality control of traditional Chinese medicine. Clinical curative effect of traditional Chinese medicine

Method used

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  • Method for determining active ingredients with myocardial protection and anti-inflammatory action in traditional Chinese medicine
  • Method for determining active ingredients with myocardial protection and anti-inflammatory action in traditional Chinese medicine
  • Method for determining active ingredients with myocardial protection and anti-inflammatory action in traditional Chinese medicine

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Embodiment 1

[0100] Example 1 Determination of active ingredients of traditional Chinese medicine with cardioprotective and anti-inflammatory effects in Tongmai Yangxin Pills

[0101] (1) Preliminary separation of chemical components

[0102] The target traditional Chinese medicine, that is, the pill of Tongmai Yangxin Pill, was placed in a mortar and ground, 10 times the amount of methanol was ultrasonically extracted for 50 minutes, and the extract was poured out, and the same method was used for ultrasonic extraction twice. The two extracts were subjected to suction filtration, and the filtrate was passed through a medium-pressure reverse-phase chromatographic column (ODS medium-pressure column) filled with octadecylsilane-bonded silica gel. Wash with pure water first, and discard the washing solution; then elute with methanol, separate the eluent through preparative liquid chromatography, and collect the separated components of the target Chinese medicine; column model: SN USA GH01324,...

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Abstract

The embodiment of the invention discloses a method for determining active ingredients with myocardial protection and anti-inflammatory action in traditional Chinese medicine. The method comprises the steps of (1) obtaining each ingredient of the target traditional Chinese medicine through preparation of liquid chromatogram; (2) determining the active ingredient with myocardial protection action through myocardial cell antioxidant model experiment; (3) determining the active ingredient with anti-inflammatory action through macrophage anti-inflammatory model experiment. According to the determined traditional Chinese medicine active ingredients with myocardial protection and anti-inflammatory action, content of the traditional Chinese medicine active ingredients is easy to determine, then, quality control on the target traditional Chinese medicine can be realized, and clinical curative effect of the target traditional Chinese medicine is guaranteed.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for determining active ingredients in traditional Chinese medicines with cardioprotective and anti-inflammatory effects. Background technique [0002] Cardiovascular disease has become one of the diseases with the highest mortality rate in today's society, and the incidence rate is increasing year by year. There are many types of cardiovascular diseases, among which ischemic heart disease is the most common type. This type of ischemic heart disease involves blockage or narrowing of coronary arteries by atherosclerotic lesions. Left ventricular aneurysm caused by myocardial ischemia, ventricular septal defect after myocardial embolism and mitral regurgitation caused by papillary muscle ischemia are common acquired heart diseases in middle-aged and elderly people. [0003] Studies have shown that this type of ischemic heart disease is mainly due to myocardial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N33/50A61K36/00A61P9/00A61P29/00
Inventor 王怡王磊高秀梅金兆祥李来来杨瑾张伯礼胡利民
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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