Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction

A technology of uterine contraction and extract, which can be used in drug combinations, medical raw materials derived from mollusks, sexual diseases, etc., can solve problems such as unreported uterine contractions.

Inactive Publication Date: 2015-08-12
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is recorded in "Qian Jin Fang" that oyster "treats metrorrhagia, leaks, redness and whitenes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1, preparation has the oyster extract that promotes postpartum uterine contraction:

[0011] (1) Appropriate amount of oyster meat, homogenized;

[0012] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;

[0013] (3) Stir and extract in a water bath at 30°C for 2 hours, centrifuge at 4000r / min for 5 minutes, take the supernatant, repeat the above operation for the residue, combine the filtrates, concentrate under reduced pressure to 1 / 3 volume, and freeze-dry to obtain the oyster extract.

Embodiment 2

[0014] Example 2: Effect of Oyster Extract on Uterine Contraction of Isolated Mice

[0015] Preparation of isolated mouse uteri: 2 days before the experiment, non-pregnant female mice were intraperitoneally injected with estradiol valerate every day to improve the sensitivity of the uterus to drugs; the mice were killed quickly by cervical dislocation, and the uteri were taken out by laparotomy to make about 1.0 cm strips of uterine smooth muscle. Put the uterus ligated with silk thread into a Maxwellian bath filled with 20ml, fix one end of the silk thread ligated to the specimen fixing hook in the bath, and connect the other end to the tension transducer, and give the uterus a load of 1g. After the uterine contraction is stable, the normal contraction curve is recorded. Add 1 drop of motherwort aqueous solution (as a control) and various concentrations of oyster extracts to each group, and after the uterine contraction is stable, use Biolap420E + The biological signal acq...

Embodiment 3

[0018] Embodiment 3: Preparation of oyster extract tablet

[0019] prescription:

[0020] Oyster Extract 100mg

[0021] Lactose 100mg

[0022] Starch 295mg

[0023] Magnesium Stearate 5mg

[0024] Total 500mg

[0025] Weigh out the main ingredients respectively, mix oyster extract powder, lactose, and starch through an 80-mesh sieve, wet granulate, dry, mix with magnesium stearate after integration, compress into tablets, and compress into tablets of 500 mg each agent.

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PUM

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Abstract

The present invention discloses an oyster extract and the application thereof in medicaments for promoting the postpartum uterine contraction. The oyster extract contains water-soluble materials extracted from the meat of the oyster and has the uterine contraction function. The oyster extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.

Description

technical field [0001] The invention relates to a new application of marine active substance oyster extract in the preparation of medicine for uterine contraction. Background technique [0002] Oysters, also known as oysters, are all of the oyster family (ostreae) animal oyster (ostreagigastnunb) and its related animals. They are marine shells with a salty taste and slightly cold nature. Suppressing liver and subduing yang; calming the nerves; softening hard masses and dispelling stagnation; astringent and astringent. Indications: vertigo and tinnitus; palpitations and insomnia; scrofula and gall tumors; lumps in the abdomen; spontaneous sweating and night sweats; nocturnal emission; uterine bleeding; leukorrhea. "Compendium of Materia Medica" records: oyster meat "eat more, can revitalize the skin, nourish the kidney and strengthen yang, and can cure deficiency and relieve erysipelas" ". "Experienced Prescriptions" records that oysters treat night sweats and cloudy sweat...

Claims

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Application Information

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IPC IPC(8): A61K35/618A61P15/04
Inventor 石振艳高华刘坤张克凌王娟
Owner QINGDAO UNIV
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