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Application of immunoglobulin to manufacturing medicine for treating erythroderma psoriaticum

An immunoglobulin and erythrodermic technology, which is applied in the application field of medicine, can solve the problems of fatal adverse reactions, toxic side effects, aggravation, etc., and achieve good human tolerance and considerable short-term and long-term curative effects

Inactive Publication Date: 2015-08-12
JIANGSU PROVINCE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used treatment methods are methotrexate, cyclosporine, etc., all of which have serious side effects. The treatment drugs themselves can aggravate and induce infection. Long-term use can cause liver fibrosis and tumors, and can cause fatal adverse reactions
Overall, patients with current erythrodermic psoriasis can be completely refractory to known treatments or die from medical treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] Through the specific clinical application of immunoglobulin in the treatment of erythrodermic psoriasis, it is shown that immunoglobulin can be used as a drug for treating erythrodermic psoriasis.

[0011] The drug used was Hualan Bioengineering Chongqing Co., Ltd., with a specification of 2.5g / bottle (5%, 50ml) for intravenous immunoglobulin (IVIg).

[0012] Patient 1. Female, 38 years old, was admitted to the hospital because of "erythema and scales on the limbs and trunk for more than 30 years, and generalized to the whole body for 2 years". After admission, it was confirmed by histopathology that it was consistent with psoriasis, and it was diagnosed as "erythrodermic psoriasis", which could not be controlled by methotrexate, retinoids, cyclosporine and glucocorticoids, and the condition continued to progress. High-dose intravenous immunoglobulin 400mg / kg / d, for 5 days, infused once a month, after a total of 5 courses of treatment, the patient's skin lesions complet...

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PUM

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Abstract

The invention discloses application of immunoglobulin to manufacturing medicine for treating erythroderma psoriaticum. The application has the advantages that the intravenous immunoglobulin [IVIg (intravenous immunoglobulin) is highly purified IgG (immunoglobulin G) extracted from healthy blood plasma individuals, the quantity of the healthy blood plasma individuals ranges from a plurality of thousands to ten thousands, the intravenous immunoglobulin is clinically applied for more than 40 years, has little adverse reaction and is excellent in human tolerance, anti-infection effects can be realized by the medicine, induction of hepatic fibrosis and tumor and mortality risks can be prevented, and significant short-term and long-term effects can be realized; a novel option and a novel idea are provided for treating the erythroderma psoriaticum and erythroderma psoriaticum with high medicine resistance and serious infection in particular.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of immunoglobulin in the preparation of medicine for treating erythrodermic psoriasis. Background technique [0002] Psoriasis is an inflammatory skin disease that seriously affects physical and mental health. The overall incidence rate is 2% to 4%, and about 25% of patients have moderate to severe psoriasis. Among them, erythrodermic psoriasis is a severe psoriasis that can involve multiple systems, often accompanied by severe visceral damage. This type is mostly insensitive to treatment, and its mortality rate can still be as high as 9% even after adequate treatment with existing drugs ~15%. The pathogenesis of psoriasis is not yet fully understood, and the occurrence of psoriasis tends to be the result of the combined effects of multiple factors. It is now considered to be a disease mediated by immune factors, mainly T lymphocytes, and patients often have severe cytok...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61P17/06A61P31/12A61P31/04
Inventor 侯麦花卢新政胡莉芳
Owner JIANGSU PROVINCE HOSPITAL
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