Centipeda minima extract product, preparation method and application thereof

A technology for extracting geraniol from geese that do not eat grass, and applying it to pharmaceutical formulas, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effects of easy large-scale production, extensive resources, and simple preparation process

Active Publication Date: 2015-08-19
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most influenza viruses are now resistant to amantadine and oseltamivir drugs

Method used

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  • Centipeda minima extract product, preparation method and application thereof
  • Centipeda minima extract product, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Grind 200g of dried goose-free grass, pass through an 80-mesh sieve, and place in supercritical CO 2 In the extractor, the extraction pressure is 30 MPa, the extraction temperature is 40° C., the flow rate is 20 liters / hour, and the extraction time is 2 hours, so as to obtain 10.8 g of supercritical carbon dioxide extract of goose and herbivore;

[0028] Dissolve the supercritical carbon dioxide extract of Goose Bubiograss in ethyl acetate, mix the sample with 12g of silica gel (100-200 mesh), and evaporate to dryness under reduced pressure to obtain the sample; take another 90g of silica gel (200-300 mesh) for dry packing Column (inner diameter × length = 3.5 × 50cm), the sample is loaded on the column, and then covered with a layer of silica gel, first eluted with petroleum ether, and then with petroleum ether and ethyl acetate (volume ratio: 8:2) Mixed solvent elution, collecting the mixed solvent eluted part, concentrating and drying to obtain 2.1 g of the mixed sol...

Embodiment 2

[0032] Grind 200g of dried goose-free grass, pass through an 80-mesh sieve, and place in supercritical CO 2 In the extractor, the extraction pressure is 20 MPa, the extraction temperature is 30 °C, the flow rate is 15 liters / hour, and the extraction time is 2 hours, and 9.9 g of the supercritical carbon dioxide extract of goose and herbivorous are obtained;

[0033] Dissolve the supercritical carbon dioxide extract of Goose Bubiograss in ethyl acetate, mix the sample with 12g of silica gel (100-200 mesh), and evaporate to dryness under reduced pressure to obtain the sample; take another 90g of silica gel (200-300 mesh) for dry packing Column (inner diameter × length = 3.5 × 50cm), put the sample on the column, then cover with a layer of silica gel, first elute with petroleum ether, and then use petroleum ether and ethyl acetate (volume ratio: 7.5:1.5) Mixed solvent elution, collecting the mixed solvent eluted part, concentrating and drying to obtain 1.8 g of the mixed solvent ...

Embodiment 3

[0037]Grind 200g of dried goose-free grass, pass through an 80-mesh sieve, and place in supercritical CO 2 In the extractor, the extraction pressure is 30 MPa, the extraction temperature is 30° C., the flow rate is 25 liters / hour, and the extraction time is 2 hours to obtain 11.4 g of supercritical carbon dioxide extract of goose and herbivore;

[0038] Dissolve the supercritical carbon dioxide extract of Goose Bubiograss in ethyl acetate, mix the sample with 12g of silica gel (100-200 mesh), and evaporate to dryness under reduced pressure to obtain the sample; take another 90g of silica gel (200-300 mesh) for dry packing Column (inner diameter × length = 3.5 × 50cm), the sample is loaded on the column, and then covered with a layer of silica gel, first eluted with petroleum ether, and then with petroleum ether and ethyl acetate (volume ratio: 9:1) Mixed solvent elution, collecting the mixed solvent eluted part, concentrating and drying to obtain 1.7 g of the mixed solvent elu...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, and concretely discloses a centipeda minima extract product, a preparation method and an application thereof. The centipeda minima extract product contains arnicolide C, 6-O-tiglic acid-11 alpha, 13-dihydro helenalin, brevilin, senecioyl dihydro helenalin, Microlenin B and arnicolide B. The method has the advantages of wide resource of centipeda minima, simple preparation technology, and easy large-scale production; the antiviral effect of the prepared centipeda minima extract product is stronger than that of a positive contrast drug ribavirin, and selection index is greater than that of ribavirin.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an extract of goose herbivore and its preparation method and application. Background technique [0002] Influenza viruses are a major threat to human health. The respiratory disease caused by influenza virus is called influenza (flu), which has the characteristics of wide prevalence, strong infectivity and high incidence. According to statistics, there are 600-1200 million influenza cases in the world every year, of which 3-5 million are severe influenza cases, 250-500 thousand people die, and the case fatality rate of severe influenza can reach 10%. [0003] Due to the variation of influenza virus antigens, conventional vaccines are still unable to effectively prevent influenza outbreaks and epidemics. Therefore, research on anti-influenza virus drugs is of great significance in the treatment of influenza. Anti-influenza drugs currently on the market can ...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K36/28A61P31/16
Inventor 王国才张晓丽张玉波李国强
Owner JINAN UNIVERSITY
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