Application of matteuccia struthiopteris total triterpenes in protection of acute alcoholic liver injury

A technology for alcohol liver damage and total triterpenes, applied in the field of biomedicine, can solve the problems of less research on the chemical components of Viburnum fern and its pharmacology and mechanism, achieve considerable development and application value, and have no toxic and side effects

Active Publication Date: 2015-08-19
SHAANXI NORMAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Up to now, there are few studies on the chemical constituents of Viburnum viburnum and their pharmacology and mechanism

Method used

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  • Application of matteuccia struthiopteris total triterpenes in protection of acute alcoholic liver injury
  • Application of matteuccia struthiopteris total triterpenes in protection of acute alcoholic liver injury
  • Application of matteuccia struthiopteris total triterpenes in protection of acute alcoholic liver injury

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0023] 1. Experimental materials

[0024] The pod fern was collected from Xunyangba Town, Ningshan County, Shaanxi Province. It was identified as Matteuccia struthiopteris (Matteuccia struthiopteris) of the genus Matteuccia Todaro in the Onocleaceae family (Onocleaceae) by Associate Professor Ma Ji, School of Life Sciences, Shaanxi Normal University; male Kunming species 70 mice (body weight 18±2g) were provided by the Animal Experiment Center of Fourth Military Medical University.

[0025] Experimental reagents: absolute ethanol, xylene, sodium chloride, and hydrochloric acid were purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; paraformaldehyde, hematoxylin, sectioned paraffin, bifendate, neutral gum, and eosin were purchased from Beijing Chemical Reagent Company; medical alanine ...

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Abstract

The invention discloses application of matteuccia struthiopteris total triterpenes in protection of acute alcoholic liver injury, belonging to the technical field of biological medicines. According to the application, a mold is made by virtue of a peroral one-time heavy drinking method; GOT and GPT biochemical indexes show that GOT and GPT can be inhibited to a certain degree by the matteuccia struthiopteris total triterpenes, and the inhibiting effect is in a positive relation with the dosage of administration; MDA and SOD biochemical indexes show that a protection mechanism of purified substances of the matteuccia struthiopteris total triterpenes to acute alcohol-induced liver injury may be related with oxidization resistance of the purified substances, and meanwhile, the purified substances are capable of assisting and enhancing original SOD activity of an organism and clearing harmful free radicals when serving as a reducing agent, thereby relieving the alcoholic liver injury; by virtue of the purified substances of the matteuccia struthiopteris total triterpenes, oxidative damage caused by lipid peroxidation, free radical attack and the like in livers can be effectively relieved, the degrees of liver cell swelling, necrosis and fatty degeneration are lowered, and cells are regulated to recover normal metabolism and physiological functions, so that the matteuccia struthiopteris total triterpenes play a certain protection role in the acute alcoholic liver injury.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of total triterpenoids of Pteridocarpus to protect acute alcoholic liver injury. Background technique [0002] At present, liver disease has become one of the diseases that generally plague human health all over the world. Liver injury refers to the invasion of the liver by external factors, resulting in damage to its structure and function. According to the different causes of liver damage, it can be roughly divided into three types: drug-induced hepatitis, alcoholic hepatitis and viral hepatitis. [0003] Alcoholic Liver Disease (ALD) refers to a series of diseases such as liver damage caused by excessive intake of alcohol. The Liver Branch of the Chinese Medical Association has established pathological diagnostic criteria for ALD based on the degree of lesions, and is generally divided into five types according to histology: mild alcoholic liv...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P1/16A23L1/29A23L33/00
Inventor 马骥杨晓艳张贵凤
Owner SHAANXI NORMAL UNIV
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