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Method for preparing 5-hydroxymethylfurfural from fructose

A technology of hydroxymethylfurfural and fructose, applied in the field of 5-hydroxymethylfurfural, can solve the problems of easy harm to the environment and human health, complex operation, low yield of 5-hydroxymethylfurfural, etc., and achieve good economical efficiency Effect

Inactive Publication Date: 2015-08-19
XIAMEN UNIV
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Problems solved by technology

This method is not only complicated to operate but also has a low yield of 5-hydroxymethylfurfural, the catalyst used cannot be recovered and most metal chlorides are poisonous and harmful, which is likely to endanger the environment and human health

Method used

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  • Method for preparing 5-hydroxymethylfurfural from fructose

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Effect test

Embodiment 1

[0019] 1g fructose, 4g choline chloride, 6×10 -3 g of hydrochloric acid (mass fraction is 38%) is placed in a round-bottomed flask and mixed uniformly, heated to 100°C in an oil bath, and reacted for 480min. -Hydroxymethylfurfural yield is 92.0% (as figure 1 ).

Embodiment 2

[0021] 1g fructose, 1g choline chloride, 4×10 -4 g hydrochloric acid (38% by mass fraction) was placed in a round-bottomed flask and mixed uniformly, heated to 110° C. in an oil bath, and reacted for 120 min. After the reaction was completed, the reaction mixture was cooled to room temperature, and the reaction product was extracted with 30 mL of dichloroethane. The yield of 5-hydroxymethylfurfural was determined to be 48.2%.

Embodiment 3

[0023] 1g fructose, 4g choline chloride, 6×10 -2 g of hydrochloric acid (mass fraction is 38%) is placed in a round bottom flask and mixed uniformly, heated to 80 ° C in an oil bath, and reacted for 180 min. After the reaction is completed, the reaction mixture is cooled to room temperature, and the reaction product is extracted with 30 mL of acetonitrile. - The yield of hydroxymethylfurfural was 45.3%.

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Abstract

The invention relates to 5-hydroxymethylfurfural, particularly a method for preparing 5-hydroxymethylfurfural from fructose. The method has the advantages of low cost, high yield, simple steps and environment friendliness. The method comprises the following steps: mixing fructose and choline chloride, adding hydrochloric acid as a catalyst, heating to react, and adding an organic extractant to extract the reaction mixture, thereby obtaining the product 5-hydroxymethylfurfural. By using the ultralow-concentration hydrochloric acid as the catalyst, the 5-hydroxymethylfurfural can be efficiently prepared in the fructose-choline chloride eutectic system, thereby being green and environment-friendly. By using the ultralow-concentration hydrochloric acid as the catalyst, the yield of the 5-hydroxymethylfurfural can reach 92%. The eutectic formed by the cheap choline chloride and fructose has favorable economical efficiency, thereby providing a novel idea for research of 5-hydroxymethylfurfural and downstream products thereof.

Description

technical field [0001] The invention relates to 5-hydroxymethylfurfural, in particular to a method for preparing 5-hydroxymethylfurfural from fructose. Background technique [0002] 5-Hydroxymethylfurfural is an important platform compound and chemical intermediate product. It contains a hydroxymethyl group and an aldehyde group in the molecule. It has good chemical reactivity and is widely used in chemical, pharmaceutical and other industries in China. Therefore, the preparation of 5-hydroxymethylfurfural from biomass-based sugars with a wide range of natural sources will promote the research and development of new energy sources and have certain positive significance for the sustainable development of society. At present, scholars have tried to convert sugars into 5-hydroxymethylfurfural in various media, such as water, organic solvents, biphasic systems and ionic liquids. Various types of catalysts are also used in sugar dehydration reactions to increase the yield of 5-h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/46
CPCC07D307/46
Inventor 曾宪海左淼李铮孙勇林鹿
Owner XIAMEN UNIV
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