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Preparation method, drug preparation and clinical application of high purity traditional Chinese medicine salvia miltiorrhiza active ingredient salvianolic acid B

An active ingredient, salvianolic acid technology, is applied to medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., which can solve the problems of low total yield, high cost, and difficulty in making up for it, and achieve low cost, Efficiency improvement, satisfactory filtering effect

Active Publication Date: 2015-09-16
NANJING CHENXIANG MEDICAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned patented technology or process is complex, or time-consuming, or labor-intensive, or consumes coal and energy, or the cost is too high, or it is only a small test, or no yield has been seen
There are two major bottlenecks in the existing technology. One is that the process is cumbersome, and most of them have to be repeatedly processed through the column in 4-5 steps, so it is difficult to realize continuous industrial production; the other is that the stability of salvianolic acid B is relatively poor. and the degradation and conversion rate produced in the separation and purification process are 10% to 15%, and the total yield is relatively low
In particular, the purity of salvianolic acid B obtained by heating, concentrating, separating and purifying under reduced pressure causes degradation of about 5% in the dilute eluent process above 98.5%, which makes the purified product unqualified and is difficult to make up for

Method used

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  • Preparation method, drug preparation and clinical application of high purity traditional Chinese medicine salvia miltiorrhiza active ingredient salvianolic acid B
  • Preparation method, drug preparation and clinical application of high purity traditional Chinese medicine salvia miltiorrhiza active ingredient salvianolic acid B
  • Preparation method, drug preparation and clinical application of high purity traditional Chinese medicine salvia miltiorrhiza active ingredient salvianolic acid B

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1.Using regular stirring and extraction with water at room temperature and ultra-short time.

[0032] Crush the salvia medicinal materials, add 10 times the amount of water for 10 minutes at room temperature for the first time, add 4 times the amount of water for 5 minutes at room temperature for the second time, combine the extracts, coarsely filter to remove most of the residue, adjust the pH of the filtrate to 3.0 ~4.0, then use cross-flow filtration and fine filtration, adjust the pH of the filtrate to 5.5~6.0, and obtain the extract for use;

[0033] 2. Separation, purification and enrichment by over-porous resin

[0034] (1) For the first time through the column for separation and purification, take the extract to pass the macroporous resin to separate the second column, column diameter: column height=1:8, medicinal materials: resin=1:2, flow rate 2BV / h; then use 4 ~10BV water (flow rate 4BV~10BV / h), 3~5BV 1~5% ethanol (flow rate 4BV~8BV / h), 2~4BV 8%~10% ethanol wash (f...

Embodiment 2

[0037] Except for the macroporous resin for separation and purification (Chromatography No. 3), it is the same as in Example 1. The total yield is 71.53% and the purity is 99.17%.

Embodiment 3

[0039] After coarse filtration removes most of the filter residue, it is filtered with a 0.45 micron microporous membrane first, and the filtrate is adjusted to pH 3.0-4.0. The other proportions and operations are the same as in Example 1, the total yield is 71.62%, and the purity is 99.13%.

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Abstract

The invention relates to a preparation method, a drug preparation and clinical application of a medicine effective component, especially relates to a preparation method of salvianolic acid B from traditional Chinese medicine salvia miltiorrhiza, and a drug preparation and clinical application, and belongs to the traditional Chinese medicine (TCM) technical field. Through use of a new method and a new idea of traditional Chinese medicine chemistry, the goal of being completely green, intelligent and circular economic can be realized, the degradation or transformation of the target compound can be effectively avoided, the preparation method has the advantages of energy conservation and emissions reduction, loss reduction, cost reduction, simple equipment and strong maneuverability, is more suitable for industrial production, and the yield is improved to 65-76% (on the basis of extract content). The present invention also discloses a variety of pharmaceutical acceptable dosage forms and new dosage forms and the clinical application in protecting of myocardial ischemia and anoxia, improvement of microcirculation, reduction of blood viscosity, inhibition of platelet aggregation and thrombosis formation and the like.

Description

Technical field [0001] The invention relates to a preparation method, preparation and clinical application of active ingredients of medicines, in particular to a method for preparing salvianolic acid B from traditional Chinese medicine salvianolic acid B, pharmaceutical preparations and clinical application thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the common and frequently-occurring diseases of middle-aged and elderly people. Every year, 60 million patients in the world receive heparin treatment (including more than 10 million in my country). Treatment of various thromboembolism diseases with chemical drugs is not satisfactory and cannot cure both the symptoms and the root causes. Traditional Chinese medicine can treat both the symptoms and the root causes. However, the quality of traditional Chinese medicines is restricted by many factors such as the place of pro...

Claims

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Application Information

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IPC IPC(8): C07D307/86A61K31/343A61K9/28A61K9/08A61P9/00A61P1/16A61P13/12A61P27/02A61P17/02
CPCA61K9/0019A61K9/0053A61K9/1623A61K9/1635A61K9/1652A61K9/2013A61K9/2031A61K9/28A61K9/5084A61K31/343A61K2300/00C07D307/86
Inventor 邢为藩吴祖栋余锡荣张璟譞
Owner NANJING CHENXIANG MEDICAL RES
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