Traditional Chinese medicine preparation for treating kidney-yang deficiency type metrorrhagia and preparing method of traditional Chinese medicine preparation
A technology of traditional Chinese medicine preparations and uterine bleeding, which is applied in the fields of medical formulas, medical preparations containing active ingredients, blood diseases, etc., and can solve problems such as irregular classification of TCM syndromes, inconsistent diagnosis and efficacy evaluation standards, etc.
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Embodiment 3
[0076] 2.1. Tested substance: name: pill of the present invention (prepared by the method of Example 3)
[0077] 2.2. Experimental animals: Grade 1 white rabbits with large ears, 10 females, weighing 2.1-2.3kg; provided by the Experimental Animal Center of the Department of Biology, Qingdao University School of Medicine;
[0078] 2.3. Test method:
[0079] 10 healthy rabbits with intact skin were selected, and the hair on both sides of the back and spine was cut off 24 hours before the test. The left and right areas of hair removal were about 4cm×4cm. During the test, take 0.2ml of the test substance and apply it on two layers of gauze of 2.5cm×2.5cm, apply it on one side of the depilated skin surface, cover it with oil paper, and fix it with adhesive tape. The skin on the other side was used as a blank control. After 4 hours of sealing, remove the cover, wash with warm water to remove the residual test substance, treat the skin reaction at the application site 1, 24 and 48 ...
Embodiment 4
[0087] Embodiment 4: skin allergy test result
[0088] Use tablet of the present invention, carry out induction and excitation contact test, treat test mouse after 24 hours and 48 hours, all do not see phenomenons such as erythema and edema in skin, have no difference with negative control group. The results show that the tablet has close to zero skin reaction intensity, that is, no skin allergy.
Embodiment 5
[0089] Embodiment 5: Long-term toxicity test data
[0090] 1. Experimental method
[0091] The guinea pigs were randomly divided into 4 groups, 15 in each group. Apply the depilatory agent evenly on both sides of the back spine of the guinea pig, so that the range of depilation is about 40 square centimeters. Clean depilatory agent, treat each group of guinea pigs after 24 hours and apply suppository solution 0.2, 0.4 and 0.8ml of the present invention respectively, contain crude drug 92,184 and 368mg respectively, another group is coated with solvent 0.8ml every day twice, continuous 30 days, Treat the general situation of the guinea pigs, and execute the animals after the experiment for hematology, blood biochemical and pathological examinations.
[0092] 2. Results
[0093] No edema, hyperemia, erythema, bleeding spots and ulcers were found in the depilated trunk area of guinea pig trunks in the above three groups of drugs. There was no significant difference between ...
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