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A blood lipid-lowering blood sugar pharmaceutical composition containing simvastatin and its application

A technology of simvastatin and its composition, which is applied in the fields of cardiovascular medicine and blood lipid-lowering blood sugar drug composition, can solve the problem of hypoglycemia without ciclopirox, achieve the correction of lipid metabolism disorder, prevent and treat macrovascular complications, and prevent and treat the occurrence and The effect of development

Inactive Publication Date: 2017-12-12
王加峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report on ciclopirox lowering blood sugar, let alone the literature report on lowering blood lipid and blood sugar after it is combined with hydroxymethylglutaryl-CoA reductase inhibitors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 50 male SD rats weighing 180-220g. After 1 week of adaptive feeding, 8 of 50 male SD rats were randomly selected as normal control group, and the remaining 42 were used as replicated animal models. The method was: high-sugar and high-fat diet (lard 10%, sucrose) 20%, cholesterol 2.5%, cholate 1%, conventional feed 66.5%) feeding. The normal control group was fed with ordinary rat feed. After 8 weeks, the model rats were intraperitoneally injected with a small dose of streptozotocin (STZ) 40 mg / kg on an empty stomach for 12 hours. The normal control group was injected with the same dose of citrate buffer as a control. After 1 week, the rats were fasted for 12 hours, and blood was taken for blood glucose measurement. The rat model with fasting blood glucose greater than 7.0 mmol / L was judged as a successful replication.

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PUM

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Abstract

The invention discloses a blood lipid / blood sugar reducing pharmaceutical composition containing simvastatin and an application of the pharmaceutical composition. The pharmaceutical composition is prepared from active ingredients and pharmaceutically available accessories; and the active ingredients include simvastatin and ciclopirox or ciclopirox olamine. The simvastatin and the ciclopirox or the ciclopirox olamine are combined to achieve a synergistic effect in reducing blood lipid and blood sugar, and the two ingredients are prepared into the pharmaceutical composition for treating the type 2 diabetes; the pharmaceutical composition is capable of correcting the dyslipidemia of a diabetic patient while reducing the blood sugar, and advantageous for preventing and treating the occurrence and development of macrovascular complications.

Description

Technical field [0001] The invention relates to a cardiovascular medicine, in particular to a medicine composition containing simvastatin for lowering blood lipid and blood sugar and its pharmaceutical application, and belongs to the technical field of medicine. Background technique [0002] Type 2 diabetes, formerly known as adult-onset diabetes, usually develops after the age of 35 to 40, accounting for more than 90% of diabetic patients. Type 2 diabetes is a pathological process from insulin resistance with relatively insufficient insulin to insufficient insulin secretion with insulin resistance. Its etiology has not been fully elucidated. It is currently recognized that diabetes is a role in environmental factors (such as changes in lifestyle) Complex genetic diseases caused by multiple genes separately or interacting. In recent years, more and more evidence has proved that inflammation plays a crucial role in the occurrence of insulin resistance and islet β-cell damage. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K31/4412A61P3/10A61P3/06
Inventor 王加峰孟娟
Owner 王加峰
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