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Blood lipid/blood sugar reducing pharmaceutical composition containing simvastatin and application of pharmaceutical composition

A technology of simvastatin and a composition is applied in the fields of cardiovascular drugs and blood lipid and blood sugar lowering pharmaceutical compositions, which can solve the problems of lowering blood sugar without ciclopirox, and achieve the purpose of correcting lipid metabolism disorders, reducing side effects, and preventing and treating macrovascular complications. Effect

Inactive Publication Date: 2015-09-30
王加峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report on ciclopirox lowering blood sugar, let alone the literature report on lowering blood lipid and blood sugar after it is combined with hydroxymethylglutaryl-CoA reductase inhibitors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 50 male SD rats, weighing 180-220g. After adaptive feeding for 1 week, randomly select 8 from 50 male SD rats as a normal control group, and the remaining 42 are used as a replica animal model. The method is: give high-sugar and high-fat feed (10% lard, sucrose 20%, cholesterol 2.5%, cholate 1%, conventional feed 66.5%) feeding. The normal control group was fed with normal rat diet. Eight weeks later, the model rats were fasted for 12 hours and injected intraperitoneally with a small dose of streptozotocin (STZ) 40 mg / kg, and the normal control group was only injected with the same dose of citrate buffer as a control. One week later, after the rats fasted for 12 hours, blood was taken to measure blood glucose, and the rat model was successfully replicated mainly when the fasting blood glucose was greater than 7.0mmol / L.

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PUM

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Abstract

The invention discloses a blood lipid / blood sugar reducing pharmaceutical composition containing simvastatin and an application of the pharmaceutical composition. The pharmaceutical composition is prepared from active ingredients and pharmaceutically available accessories; and the active ingredients include simvastatin and ciclopirox or ciclopirox olamine. The simvastatin and the ciclopirox or the ciclopirox olamine are combined to achieve a synergistic effect in reducing blood lipid and blood sugar, and the two ingredients are prepared into the pharmaceutical composition for treating the type 2 diabetes; the pharmaceutical composition is capable of correcting the dyslipidemia of a diabetic patient while reducing the blood sugar, and advantageous for preventing and treating the occurrence and development of macrovascular complications.

Description

technical field [0001] The invention relates to a cardiovascular medicine, in particular to a blood lipid-lowering blood sugar pharmaceutical composition containing simvastatin and its pharmaceutical application, belonging to the technical field of medicine. Background technique [0002] Type 2 diabetes, formerly known as adult-onset diabetes, usually occurs after the age of 35 to 40, accounting for more than 90% of diabetic patients. Type 2 diabetes is a pathological process from insulin resistance with relative insulin deficiency to insulin secretion with insulin resistance. Complex genetic diseases caused by multiple genes individually or interacting. In recent years, more and more evidences have proved that inflammation plays a crucial role in the occurrence of insulin resistance and pancreatic β-cell injury. The main causes of type 2 diabetes include obesity, physical inactivity and stress. Stress includes stress, exhaustion, mental stimulation, trauma, surgery, chil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K31/4412A61P3/10A61P3/06
Inventor 白玲强
Owner 王加峰
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