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Medicinal composition for preventing and treating cardiovascular heart disease and its preparation

A technology for the prevention and treatment of cardiovascular and composition, which is applied in the direction of cardiovascular system diseases, metabolic diseases, drug combinations, etc., can solve the problems of large side effects, achieve the effects of correcting lipid metabolism disorders, increasing the number, and improving microcirculation

Inactive Publication Date: 2006-10-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

HMG-CoA reductase inhibitors are new powerful blood lipid-lowering drugs that have emerged in the past 20 years, but most of them are artificially synthesized chemical drugs, such as statins, which have serious side effects after long-term use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Put the usual industrial raw material soybean hypocotyls in a hot air drying oven to heat and dry the enzymes at high temperature (temperature 100° C., time 15 minutes). After being pulverized by an industrial pulverizer, the soybean hypocotyl powder is passed through a 60 sieve.

[0020] 2. Put the hawthorn in a hot air drying box and dry it at high temperature (temperature 80°C, time 20 minutes). After being pulverized by an industrial pulverizer, the hawthorn powder is passed through a 60-mesh sieve, and then the hawthorn powder and soybean hypocotyl powder are mixed according to the ratio. Mix evenly, and then granulate through the pharmaceutical industry granulation device.

[0021] 3. The natural red yeast rice, soybean isoflavones, broken ganoderma lucidum spores, and ganoderma lucidum extract, which are used as medicinal industrial raw materials, are tested to contain 1.5% of Monacolin K in natural red yeast rice (no citrinin was detected), and soybean isoflav...

Embodiment 2

[0025] 1. Soak the soybeans in cold water for 3 hours until the seed coat expands and the hypocotyl elongates to the initial germination state. Put it in an industrial peeling device with low-speed stirring and rolling to peel off the soybean seed cotyledon and the seed coat, and put the soybean seeds in the separation tank. The skin is separated from the cotyledons, and then the soybean cotyledons are divided into petals and soybean hypocotyls are separated and peeled off by medium-speed stirring in a general industrial peeling device, and then the separated soybean hypocotyls are heat-dried at high temperature in a hot air drying oven and dried ( Temperature 110 DEG C, time 18 minutes), after being pulverized by an industrial pulverizer, the soybean hypocotyl powder is passed through an 80 sieve.

[0026] 2. Put the hawthorn in a hot air drying box and dry it at high temperature (temperature 100°C, time 18 minutes). After being pulverized by an industrial grinder, the hawthor...

Embodiment 3

[0031] 1. Put the usual industrial raw material soybean hypocotyls in a hot air drying oven to heat out the enzyme at high temperature (temperature 105°C, time 13 minutes). After being crushed by an industrial grinder, the soybean hypocotyl powder is passed through a 60 sieve.

[0032] 2. Put the hawthorn in a hot air drying box and dry it at high temperature (temperature 100°C, time 15 minutes). After being pulverized by an industrial pulverizer, the hawthorn powder is passed through a 80-mesh sieve, and then the hawthorn powder and soybean hypocotyl powder are mixed according to the ratio. Mix evenly, and then granulate through the pharmaceutical industry granulation device.

[0033] 3. The natural red yeast rice, soybean isoflavones, broken Ganoderma lucidum spores, and Ganoderma lucidum extract, which are used as medicinal industrial raw materials, are tested to contain 1.4% of Monacolin K in natural red yeast rice (no citrinin was detected), and soybean isoflavones The co...

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Abstract

The invention relates to a composition mainly composed of monascus isoflavone and a preparation method thereof. The composition is composed of red yeast rice, soybean isoflavones, soybean hypocotyl, broken ganoderma spores, ganoderma lucidum extract and hawthorn. Spores: Ganoderma lucidum extract: Hawthorn = (0.02-2): (0.1-2): (0.1-10): (0.1-10): (0.1-10): (0.1-10). The preparation method comprises the following steps: soybean hypocotyls (soybean hypocotyls at germination stage can also be selected) and hawthorn are subjected to high-temperature enzymatic inactivation or drying, pulverization, sieving, mixing and granulation according to the proportion, and natural red yeast rice, soybean isoflavones, crushed After the Ganoderma lucidum spores and Ganoderma lucidum extract are mixed and granulated according to the proportion, the granule granule or tablet of the composition of the present invention is obtained through the usual pharmaceutical industry granule granule or tablet production process. The composition of the invention can be used as medicine or health food for improving and lowering cholesterol, lowering blood fat, lowering blood pressure and preventing and treating cardiovascular diseases.

Description

technical field [0001] The invention relates to a composition mainly composed of monascus isoflavone, which can improve and lower cholesterol, lower blood fat, lower blood pressure and prevent and treat cardiovascular diseases, and a preparation method of the composition. Background technique [0002] Studies have found that about 70% of cholesterol in the human body is synthesized by itself, and the synthesis process mainly includes five steps: (1) acetyl-CoA is condensed into HMG-CoA; (2) HMG-CoA is catalyzed by HMG-CoA reductase (3) MVA is converted into isopentenol pyrophosphate (IPP); (4) IPP is converted into squalene; (5) squalene is finally synthesized into cholesterol. In the whole synthesis pathway, HMG-CoA reductase is the key enzyme controlling the synthesis rate, and inhibiting the activity of this enzyme can effectively reduce or block the synthesis of cholesterol in the body. [0003] In 1979, Akira Endo of Japan isolated an active substance that can inhibit ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K36/48A61K36/074A61K36/06A61K9/16A61K9/20A61P3/06A61P9/12A61P9/10
Inventor 刘昕徐安龙王江海鲁佳慧陈汉聪黄晓霓
Owner SUN YAT SEN UNIV
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