Titanium/tricalcium phosphate composite applied to bone implanting material and preparation method of titanium/tricalcium phosphate composite

A technology of bone implant materials and composite materials, which is applied in the field of titanium/tricalcium phosphate composite materials and its preparation, can solve the problems of non-degradability, achieve excellent biological activity, improve the speed and ability of bone repair, and excellent mechanical properties Effect

Inactive Publication Date: 2015-09-30
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

HA is the most stable phase among calcium phosphate compounds (solubility at 37°C is 0.000096mg L -1 ) (Carrodeguas RG, et.al., Acta Biomaterialia.2011, 7:3536-3546.), so although the above-mentioned titanium-based composite material has improved bioactivity, it does not have degradability

Method used

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  • Titanium/tricalcium phosphate composite applied to bone implanting material and preparation method of titanium/tricalcium phosphate composite
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  • Titanium/tricalcium phosphate composite applied to bone implanting material and preparation method of titanium/tricalcium phosphate composite

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Embodiment 1

[0038] A titanium / tricalcium phosphate composite material applied to bone implant materials of the present invention has a continuous network structure, the quality of tricalcium phosphate in the composite material accounts for 10wt% of the composite material mass, and the tricalcium phosphate is α- TCP.

[0039] The preparation method of the present embodiment titanium / tricalcium phosphate composite material, the steps are as follows:

[0040] 1) Weigh Ca(NO 3 ) 2 4H 2 O and NH 4 h 2 PO 4 , the Ca(NO 3 ) 2 4H 2 O formulated as Ca 2+ Calcium nitrate solution with a concentration of 0.45mol / L, NH 4 h 2 PO 4 Formulated as PO 4 3- Ammonium dihydrogen phosphate solution with a concentration of 0.3mol / L.

[0041] 2) Add the calcium nitrate solution dropwise to the ammonium dihydrogen phosphate solution at a rate of 2 mL / min, and add ammonia water to control the pH of the mixed solution to 7.5, then stir it magnetically for 4 hours, and separate it by suction filtrati...

Embodiment 2

[0045] A titanium / tricalcium phosphate composite material applied to bone implant materials of the present invention has a continuous network structure, the quality of tricalcium phosphate in the composite material accounts for 20wt% of the composite material mass, and the tricalcium phosphate is α- TCP.

[0046] The preparation method of the present embodiment titanium / tricalcium phosphate composite material, the steps are as follows:

[0047] 1) Weigh Ca(NO 3 ) 2 4H 2 O and NH 4 h 2 PO 4 , the Ca(NO 3 ) 2 4H 2 O formulated as Ca 2+ Calcium nitrate solution with a concentration of 0.45mol / L, NH 4 h 2 PO 4 Formulated as PO 4 3- Ammonium dihydrogen phosphate solution with a concentration of 0.3mol / L.

[0048] 2) Calcium nitrate solution was added dropwise to ammonium dihydrogen phosphate solution at a rate of 2 mL / min, and ammonia water was added to control the pH of the mixed solution to be 7.5, then magnetically stirred for 4 hours, and precipitated after centr...

Embodiment 3

[0052] A titanium / tricalcium phosphate composite material applied to bone implant materials of the present invention has a continuous network structure, the quality of tricalcium phosphate in the composite material accounts for 30wt% of the composite material mass, and the tricalcium phosphate is α- TCP.

[0053] The preparation method of the present embodiment titanium / tricalcium phosphate composite material, the steps are as follows:

[0054] 1) Weigh Ca(NO 3 ) 2 4H 2 O and NH 4 h 2 PO 4 , the Ca(NO 3 ) 2 4H 2 O formulated as Ca 2+ Calcium nitrate solution with a concentration of 0.45mol / L, NH 4 h 2 PO 4 Formulated as PO 4 3- Ammonium dihydrogen phosphate solution with a concentration of 0.3mol / L.

[0055] 2) Calcium nitrate solution was added dropwise to ammonium dihydrogen phosphate solution at a rate of 2 mL / min, and ammonia water was added to control the pH of the mixed solution to be 7.5, then magnetically stirred for 3 hours, and precipitated after centr...

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Abstract

The invention discloses a titanium/tricalcium phosphate composite applied to a bone implanting material. The titanium/tricalcium phosphate composite adopts a continuous network structure, tricalcium phosphate in the composite accounts for 10-50 wt% of the mass of the composite and is alpha-TCP or a mixture of alpha-TCP and beta-TCP, and the mass ratio of alpha-TCP to beta-TCP is (1-9): 1. A preparation method of the titanium/tricalcium phosphate composite comprises the following steps: (1) preparing a solution; (2) preparing tricalcium phosphate; (3) mixing and ball-milling titanium and tricalcium phosphate, and then preparing the titanium/tricalcium phosphate composite by the spark plasma sintering method. The titanium/tricalcium phosphate composite adopts a metal and ceramic continuous network structure, and has not only a favorable mechanical property, strength and an elastic modulus, which are close to human bones, but also excellent bioactivity and degradability.

Description

technical field [0001] The invention relates to a novel composite material and a preparation method thereof, in particular to a titanium / tricalcium phosphate composite material applied to bone implant materials and a preparation method thereof. Background technique [0002] Titanium and titanium alloys have good mechanical properties, toughness, biocompatibility, and corrosion resistance, and are widely used as bone implant materials in load-bearing parts. However, titanium and titanium alloys have two major problems as biomaterials. One is that the mechanical properties do not match, and the elastic modulus is much higher than that of human bone, resulting in the main stress being borne and conducted by the implanted bone. Due to the "stress shielding" of the host bone, The lack of sufficient stress stimulation leads to osteolysis, which is also one of the important reasons for the loosening of the prosthesis; the second is that titanium and titanium alloys do not have biol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42
Inventor 谭彦妮刘咏夏智斌汤菡纯周睿
Owner CENT SOUTH UNIV
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