A kind of sodium bicarbonate injection double-layer aseptic soft bag packaging system and preparation method thereof
A technology of sodium bicarbonate and packaging system, applied in the field of pharmaceutical packaging, can solve the problems of falling off, the surface of soda lime glass is easily corroded and changed, and achieve the effect of easy production
Active Publication Date: 2018-04-10
SHIJIAZHUANG NO 4 PHARMA
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Problems solved by technology
But the glass bottle packaging has the following shortcomings: (1) the quality is fragile and fragile, and the existence of this deficiency brings great inconvenience to the clinical use of the glass bottle packaging; (2) air must be introduced during infusion. There is likely to cause secondary pollution and changes in the properties of the glass bottle during the infusion process; (3) the surface of the soda-lime glass is easily corroded and falls off, etc., along with the volatilization of carbon dioxide in the glass bottle package, the The alkalinity gradually increases, which makes the surface of the soda-lime glass susceptible to corrosion and peeling off, which may seriously endanger the safety of infusion and patients
However, this structure has the following problems in the subsequent sterilization process: (1) If the inner bag is sterilized at high temperature first, and then the outer bag with barrier properties is added
In this case, on the one hand, it is easy to cause the air in the inner bag to leak out during high temperature sterilization; on the other hand, the outer bag is sealed after sterilization, and the inner bag is no longer sterile
Moreover, because carbon dioxide gas or nitrogen is filled between the inner and outer bags, it is difficult to seal the outer bag of this infusion bag, which is easy to cause the bag to break, and it is difficult to ensure product safety.
(2) If the overall high-temperature sterilization of the infusion package is carried out after adding an outer bag with barrier properties, the presence of carbon dioxide gas or nitrogen may prevent heat penetration, resulting in uneven sterilization; and the gas may expand during heating , easy to cause the bag to break or deform
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[0038] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and examples. Unless clearly defined otherwise, those skilled in the art should consider the chemical terms used throughout the description herein to have their ordinary meanings as used in the art.
[0039] Such asfigure 1 As shown, in an embodiment of the present invention, a double-layer aseptic soft bag packaging system for sodium bicarbonate injection is provided, which includes: a non-PVC co-extruded film inner bag 10 and a barrier protection bag 20 . Wherein the non-PVC co-extruded film inner bag 10 is provided with a medicament cavity 15 for containing sodium bicarbonate injection liquid medicine 17 and carbon dioxide protective gas 18; A sealed cavity 21, wherein the non-PVC co-extruded film inner ba...
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The invention discloses a sodium bicarbonate injection double-layer aseptic soft bag packaging system and a preparation method thereof. The packaging system includes: a non-PVC co-extruded film inner bag, which is provided with a medicament cavity for containing sodium bicarbonate injection liquid and carbon dioxide protective gas; a barrier protection bag, which is provided with a container for accommodating the non-PVC co-extruded film inner bag. A sealed cavity, wherein the non-PVC co-extruded film inner bag is hermetically accommodated in the sealed cavity, wherein the sealed cavity is a vacuum sealed cavity. The packaging system forms a vacuum-sealed cavity in the barrier protection bag, and accommodates the non-PVC co-extruded film inner bag in the vacuum-sealed cavity, which can prevent the problem of gas permeation and overcome the problem of filling the sealed cavity with gas. The defects of bag body deformation or broken bag caused by gas expansion during high temperature sterilization improve the quality and safety of the double-layer aseptic soft bag packaging system for sodium bicarbonate injection, and also improve the heat penetration of the sterilization process Force, improve the sterilization effect.
Description
technical field [0001] The invention relates to the field of medical packaging, in particular to a sodium bicarbonate injection double-layer aseptic soft bag packaging system and a preparation method thereof. Background technique [0002] The packaging of infusion solutions has gone through glass bottles and plastic bottles, and the process from bottle making to filling and sealing is basically completed in the same clean workshop, and clinical use has achieved progress from fully open to semi-open. In order to avoid secondary pollution and realize fully airtight infusion, the infusion with plastic bag packaging that can shrink automatically has been researched and designed. Currently the most widely used are non-PVC co-extruded film bags and polypropylene stand-up bags. [0003] With the development of clinical application of infusion, the varieties of infusion are no longer just simple saline and glucose. A batch of therapeutic and nutritional infusions such as sodium bi...
Claims
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IPC IPC(8): A61J1/10A61J1/14
Inventor曲继广李建刚王立江代军朋李士磊崔雪妹焦翠欢韩锡镇刘晓娟
OwnerSHIJIAZHUANG NO 4 PHARMA