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Application of traditional Chinese medicine composition to preparation of drugs for treating ischemic brain injury

A technology for ischemic brain injury and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for the treatment of ischemic brain injury, can solve problems such as lack, and achieve the effect of highlighting substantive characteristics

Inactive Publication Date: 2015-11-18
朱万良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to long-term neglect, so far, there is no clinically effective treatment guideline based on large-scale, multi-center evidence-based medical evidence

Method used

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  • Application of traditional Chinese medicine composition to preparation of drugs for treating ischemic brain injury
  • Application of traditional Chinese medicine composition to preparation of drugs for treating ischemic brain injury

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1: Take 15g of purple jade plate, 12g of Tuxiangru, 18g of Dawawei, 18g of Chuancao, 14g of Radix chinensis root, 12g of chrysanthemum, 18g of Ludou heart, and 20g of Shen soybean, add water to decoct 2 times, the second time The amount of water added once is 10 times the weight of the medicinal materials, decocted for 2 hours, the amount of water added for the second time is 8 times the weight of the medicinal materials, decocted for 1 hour, the decoctions are combined, concentrated, dried, and pulverized to obtain Chinese medicine composition granules, Concentration conditions are: 0.07MPa, 60-70 ° C under reduced pressure and concentration to 65 ° C relative density of 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0018] Embodiment 2: The influence of traditional Chinese medicine composition on rat local cerebral ischemic injury

[0019] 1. Test drugs and materials: Prepare test drugs according to the method in Example 1 above. SD rats, both male and female, weighing 190-210g. Positive control drug: Tianbaoning, produced by Kangenbei Group Pharmaceutical Co., Ltd., each tablet contains 40 mg of Ginkgo biloba extract.

[0020] 2, method: Chinese medicine composition is to rat middle artery thrombosis (MCAO) model test: 60 rats are randomly divided into six groups, namely sham operation control group, MCAO model group, 3 groups of drug administration groups, Tianbaoning group ( 24mg / kg). Gastrointestinal administration before modeling, once a day, a total of seven times of administration, sham operation control group, MCAT model group, given the same amount of drinking water (1ml / 100g), intragastric administration once after modeling. Rats were anesthetized by intraperitoneal injection...

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Abstract

The invention discloses application of a traditional Chinese medicine composition to the preparation of the drugs for treating ischemic brain injury. The traditional Chinese medicine composition is prepared from the following materials: 15 parts of uvaria microcarpa, 12 parts of elsholtzia ciliata hyland, 18 parts of lepisorus macrosphaerus, 18 parts of cheilosoria chusana, 14 parts of Japanese raspberry root, 12 parts of stachys sieboldi, 18 parts of textile screw pine shoot and 20 parts of cassia agnes. The traditional Chinese medicine composition can be used for treating ischemic brain injury.

Description

technical field [0001] The invention relates to a new application of a Chinese medicine composition, in particular to an application of the Chinese medicine composition in preparing medicine for treating ischemic brain injury. Background technique [0002] Ischemic brain injury is a secondary injury secondary to a primary disease. If it is not treated in time, it will not only aggravate the primary disease, but also make the treatment of the primary disease more difficult, delay the recovery of the patient, increase the incidence of various complications, increase the mortality rate, disability rate and dementia Rate. Since there are differences in principle between the management of ischemic brain injury and the management of cerebral hemorrhage itself, especially the management of early blood pressure, the choice of antiplatelet / anticoagulant drugs and hemostatic drugs, as well as dehydrating agents, diuretics and statins The use of the two, the processing principles of ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/10
Inventor 朱万良
Owner 朱万良
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