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Erythromycin thiocyanate soluble powder and preparation method thereof

A erythromycin thiocyanate, soluble technology, applied in the direction of powder delivery, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of inconvenience, slow dissolution speed, solubilization, and solubilization are not obvious, and achieve good solubility , the effect of solubility enhancement

Active Publication Date: 2015-12-16
BAODING JIZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water-solubility of erythromycin thiocyanate is poor, can't meet the requirement of preparing soluble powder, often needs to add co-solvent, but acidic co-solvent can cause the decomposition of erythromycin thiocyanate and limit its use, other co-solvents (such as PEG etc.), solubilizers (such as sodium lauryl sulfate, etc.) have no obvious effect on its solubility and solubilization
The erythromycin thiocyanate soluble powder that common method is made can only reach about 0.15g / L (calculated as erythromycin) in water, and dissolving speed is relatively slow, needs continuous stirring for a long time when dissolving, and gives animals The medicine is inconvenient

Method used

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  • Erythromycin thiocyanate soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the preparation of 5% (in erythromycin) erythromycin thiocyanate soluble powder

[0021] Add 25g of erythromycin thiocyanate (20g as erythromycin) into 2L of water, stir, add 50g of sodium citrate, 10g of citric acid and 8g of sodium dihydrogen phosphate in turn, stir to dissolve, and use 10mol / L of NaOH solution Adjust the pH to 5.1, add 307g of water-soluble starch, and spray-dry to obtain about 400g of erythromycin thiocyanate soluble powder, with a content of 5% (calculated as erythromycin).

Embodiment 2

[0023] Add 31g of erythromycin thiocyanate (25g as erythromycin) into 2.5L of water, stir, then add 75g of sodium citrate, 25g of citric acid and 7.5g of sodium dihydrogen phosphate, stir to dissolve, and use 10mol / L NaOH solution was used to adjust the pH to 4.8, 361.5 g of Jiayi powder was added, and spray-dried to obtain about 500 g of erythromycin thiocyanate soluble powder with a content of 5% (calculated as erythromycin).

Embodiment 3

[0025] Add 25g of erythromycin thiocyanate (20g in terms of erythromycin) into 1.0L of water, stir, then add 75g of sodium citrate, 28g of citric acid and 12g of sodium dihydrogen phosphate, stir to dissolve, and use 10mol / L of NaOH The pH of the solution was adjusted to 5.0, 260 g of Jiayi powder was added, and spray-dried to obtain about 400 g of erythromycin thiocyanate soluble powder with a content of 5% (calculated as erythromycin).

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Abstract

The invention provides erythromycin thiocyanate soluble powder and relates to the field of veterinary medicine. The erythromycin thiocyanate soluble powder is prepared from, by mass, 1%-20% of erythromycin thiocyanate, 2%-40% of sodium citrate, 1%-20% of citric acid, 1%-5% of sodium dihydrogen phosphate, and the balance auxiliary materials. The invention further provides a method for preparing the erythromycin thiocyanate soluble powder. The prepared erythromycin thiocyanate soluble powder is good in solubility in water, the solubility of the erythromycin thiocyanate soluble powder in water reaches 5 g / L (counting as erythromycin), and the solubility of the erythromycin thiocyanate soluble powder in water is greatly increased. A water solution obtained after the erythromycin thiocyanate soluble powder is dissolved in water is very stable at the temperature of 25 DEG C and under the light shielding condition, and the degradation amount after 4 h is smaller than 5%.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to erythromycin thiocyanate soluble powder and a preparation method thereof. Background technique [0002] Erythromycin thiocyanate is mainly administered through drinking water to treat poultry infectious diseases caused by Gram-positive bacteria and mycoplasma. The water solubility of erythromycin thiocyanate is poor, can't meet the requirement of preparing soluble powder, often needs to add cosolvent, but acidic cosolvent can cause the decomposition of erythromycin thiocyanate and limit its use, other cosolvents (such as PEG etc.), solubilizers (such as sodium lauryl sulfate, etc.) have no obvious effect on its dissolution and solubilization. The erythromycin thiocyanate soluble powder that common method is made can only reach about 0.15g / L (calculated as erythromycin) in water solubility, and dissolving speed is relatively slow, needs contin...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/7048A61K47/12A61K47/04A61K47/46A61K47/40A61P31/04
Inventor 刘波吴里明杨芳岳永波郧祺
Owner BAODING JIZHONG PHARMA
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