5 results about "Erythromycin thiocyanate" patented technology

The invention belongs to the field of biological pharmacy post-treatment, and particularly relates to a harmless treatment method for erythromycin thiocyanate fungus residues. By screening conditions in the preparation process, the erythromycin thiocyanate fungus residues are subjected to flocculation, squeezing and secondary drying treatment. Under the preferable process conditions, the titer residual value of the treated mushroom dregs is 4.2 ppm or below; and the equipment is small in burden, low in damage rate, high in efficiency and suitable for industrial application. The method is simple in process, convenient to operate and small in dust pollution; the plate frame squeezing can separate mushroom dregs from water, the water is fully utilized, the drying machine can dry the mushroom dregs, the titer residue of the mushroom dregs is reduced to the minimum through disc secondary drying, the transportation is convenient, manpower and material resources are saved, the cost is saved for enterprises, the harm to human environment and health is reduced, and the application prospect is good.

The invention relates to a method for purifying erythromycin thiocyanate, which comprises the following steps of: firstly, carrying out decoloration and impurity removal pretreatment on alkalized erythromycin fermentation liquor through combination of activated carbon adsorption and diatomite packed column filtration, then combining an acetone extract salifying primary crystallization method and a crystallization mother liquor salting-out secondary crystallization method, and finally drying to obtain the erythromycin thiocyanate. According to the method, the extraction process of erythromycin thiocyanate is optimized, the yield is increased while the purity of the erythromycin thiocyanate product is effectively improved, the content of erythromycin thiocyanate A reaches 90% or above, and the yield reaches 88% or above.

This invention provides a method for purifying erythromycin thiocyanate. The method first involves dissolving crude erythromycin thiocyanate in an ester solvent under alkaline conditions; then adding thiocyanate and crystallizing under neutral to slightly alkaline conditions; followed by membrane-assisted cooling for secondary crystallization; and finally, filtration and drying to obtain purified erythromycin thiocyanate. This invention uses a membrane-assisted cooling coupled crystallization method instead of the traditional cooling crystallization method, successfully controlling the nucleation rate, eliminating explosive nucleation, and significantly improving the content and yield of erythromycin thiocyanate A.

The application discloses an energy-saving and recycling erythromycin thiocyanate wastewater treatment method and system, which comprises the following steps: firstly pretreating high-concentration erythromycin thiocyanate wastewater; adding an oxidizing agent to effluent water after the first pretreatment and evaporating and concentrating; carrying out anaerobic ammonia oxidation treatment on condensate generated in the evaporation and concentration; mixing mother liquor generated in the evaporation and concentration with low-concentration erythromycin thiocyanate wastewater and secondarily pretreating the mixed wastewater; mixing effluent water after the secondary pretreatment with effluent water after the anaerobic ammonia oxidation treatment and carrying out hydrolytic acidification treatment on the mixed effluent water; sequentially carrying out anaerobic treatment, advanced biochemical treatment and advanced catalytic oxidation treatment on effluent water after the hydrolytic acidification treatment, and discharging the effluent water up to the standard. The application combines the oxidation process with the evaporation process, simultaneously and efficiently removes erythromycin titer and thiocyanate, and eliminates the inhibition of the anaerobic biological process.

The invention provides a method for measuring the content of trimethylchlorosilane, and relates to the field of chemical engineering, and the specific method is as follows: preparing a trimethylchlorosilane contrast solution and a test solution, detecting by adopting a gas chromatographic method, and calculating the content by using an external standard method. The method is characterized in that a capillary chromatographic column taking 6%-cyanopropyl phenyl-94%-polydimethylsiloxane as a stationary phase is adopted, n-heptane is taken as a solvent, carrier gas is nitrogen, and effective separation of trimethylchlorosilane and impurities is realized through an optimized gradient heating program. The method is high in precision (RSD is less than or equal to 2%), good in accuracy (average recovery rate is 99.6%), excellent in linear relation (r is equal to 1.000), simple and convenient to operate and free of derivatization step, and is suitable for efficient and reliable determination of trimethylchlorosilane raw materials and residual solvents thereof in drugs (such as erythromycin thiocyanate).