3 results about "Erythromycin thiocyanate" patented technology

This invention provides a method for purifying erythromycin thiocyanate. The method first involves dissolving crude erythromycin thiocyanate in an ester solvent under alkaline conditions; then adding thiocyanate and crystallizing under neutral to slightly alkaline conditions; followed by membrane-assisted cooling for secondary crystallization; and finally, filtration and drying to obtain purified erythromycin thiocyanate. This invention uses a membrane-assisted cooling coupled crystallization method instead of the traditional cooling crystallization method, successfully controlling the nucleation rate, eliminating explosive nucleation, and significantly improving the content and yield of erythromycin thiocyanate A.

The application discloses an energy-saving and recycling erythromycin thiocyanate wastewater treatment method and system, which comprises the following steps: firstly pretreating high-concentration erythromycin thiocyanate wastewater; adding an oxidizing agent to effluent water after the first pretreatment and evaporating and concentrating; carrying out anaerobic ammonia oxidation treatment on condensate generated in the evaporation and concentration; mixing mother liquor generated in the evaporation and concentration with low-concentration erythromycin thiocyanate wastewater and secondarily pretreating the mixed wastewater; mixing effluent water after the secondary pretreatment with effluent water after the anaerobic ammonia oxidation treatment and carrying out hydrolytic acidification treatment on the mixed effluent water; sequentially carrying out anaerobic treatment, advanced biochemical treatment and advanced catalytic oxidation treatment on effluent water after the hydrolytic acidification treatment, and discharging the effluent water up to the standard. The application combines the oxidation process with the evaporation process, simultaneously and efficiently removes erythromycin titer and thiocyanate, and eliminates the inhibition of the anaerobic biological process.

The invention provides a method for measuring the content of trimethylchlorosilane, and relates to the field of chemical engineering, and the specific method is as follows: preparing a trimethylchlorosilane contrast solution and a test solution, detecting by adopting a gas chromatographic method, and calculating the content by using an external standard method. The method is characterized in that a capillary chromatographic column taking 6%-cyanopropyl phenyl-94%-polydimethylsiloxane as a stationary phase is adopted, n-heptane is taken as a solvent, carrier gas is nitrogen, and effective separation of trimethylchlorosilane and impurities is realized through an optimized gradient heating program. The method is high in precision (RSD is less than or equal to 2%), good in accuracy (average recovery rate is 99.6%), excellent in linear relation (r is equal to 1.000), simple and convenient to operate and free of derivatization step, and is suitable for efficient and reliable determination of trimethylchlorosilane raw materials and residual solvents thereof in drugs (such as erythromycin thiocyanate).