10 results about "Erythromycin thiocyanate" patented technology

The present invention provides a method for treating erythromycin thiocyanate residue, which comprises: A) subjecting erythromycin thiocyanate residue to electron beam irradiation treatment; B) inoculating anaerobic sludge with erythromycin thiocyanate residue obtained in step A) for anaerobic fermentation; C) subjecting the fermentation liquid obtained in step C) to electron beam irradiation deep treatment, enriching and concentrating the obtained fermentation liquid, and obtaining a biomass carbon source. The method for treating erythromycin thiocyanate residue provided by the present application combines electron beam pretreatment with anaerobic fermentation, and further subjecting the obtained fermentation liquid to electron beam deep treatment, thereby solving the problems of antibiotic residues and resistance genes in fermentation-type erythromycin thiocyanate residue; solving the problem that the amount of acid, alkali and oxidant added in the erythromycin thiocyanate residue treatment process is large, resulting in excessively high inorganic salt content in the subsequent residue; solving the problem that a large amount of clean water needs to be added for dilution, and the problem that macromolecular organic matter such as protein and lipid in mycelium is difficult to be utilized by microorganisms.

The invention provides an erythromycin thiocyanate solution and a preparation method thereof, every 100 mL of the erythromycin thiocyanate solution contains 5-30 g of erythromycin thiocyanate (based on erythromycin), 7.8-31.4 g of a cosolvent, 0.2-0.5 g of a preservative, 0.1-0.4 g of an antioxidant, 0.5-1.4 g of a pH regulator, and the balance of a solvent, the cosolvent comprises L-arginine, the preservative comprises sorbic acid, and the pH regulator comprises sodium hydroxide. The solubility of erythromycin thiocyanate can be remarkably improved by combining sorbic acid and L-arginine. The erythromycin thiocyanate solution is stable in property and remarkable in effect, the preparation method is simple, the existing technical problems of erythromycin thiocyanate are effectively solved, and the erythromycin thiocyanate solution is suitable for large-scale industrial production and clinical use.

The invention belongs to the field of biological pharmacy post-treatment, and particularly relates to a harmless treatment method for erythromycin thiocyanate fungus residues. By screening conditions in the preparation process, the erythromycin thiocyanate fungus residues are subjected to flocculation, squeezing and secondary drying treatment. Under the preferable process conditions, the titer residual value of the treated mushroom dregs is 4.2 ppm or below; and the equipment is small in burden, low in damage rate, high in efficiency and suitable for industrial application. The method is simple in process, convenient to operate and small in dust pollution; the plate frame squeezing can separate mushroom dregs from water, the water is fully utilized, the drying machine can dry the mushroom dregs, the titer residue of the mushroom dregs is reduced to the minimum through disc secondary drying, the transportation is convenient, manpower and material resources are saved, the cost is saved for enterprises, the harm to human environment and health is reduced, and the application prospect is good.

The invention relates to a method for purifying erythromycin thiocyanate, which comprises the following steps of: firstly, carrying out decoloration and impurity removal pretreatment on alkalized erythromycin fermentation liquor through combination of activated carbon adsorption and diatomite packed column filtration, then combining an acetone extract salifying primary crystallization method and a crystallization mother liquor salting-out secondary crystallization method, and finally drying to obtain the erythromycin thiocyanate. According to the method, the extraction process of erythromycin thiocyanate is optimized, the yield is increased while the purity of the erythromycin thiocyanate product is effectively improved, the content of erythromycin thiocyanate A reaches 90% or above, and the yield reaches 88% or above.

This invention provides a method for purifying erythromycin thiocyanate. The method first involves dissolving crude erythromycin thiocyanate in an ester solvent under alkaline conditions; then adding thiocyanate and crystallizing under neutral to slightly alkaline conditions; followed by membrane-assisted cooling for secondary crystallization; and finally, filtration and drying to obtain purified erythromycin thiocyanate. This invention uses a membrane-assisted cooling coupled crystallization method instead of the traditional cooling crystallization method, successfully controlling the nucleation rate, eliminating explosive nucleation, and significantly improving the content and yield of erythromycin thiocyanate A.

The invention discloses a process for preparing a liquid fertilizer from erythromycin thiocyanate waste liquid, and relates to the technical field of liquid fertilizers. When the erythromycin thiocyanate waste liquid liquid fertilizer is prepared, titanium dioxide solids are prepared from tetrabutyl titanate and absolute ethyl alcohol under the action of ammonia water, the titanium dioxide solids are subjected to ultrasonic treatment and then loaded with copper ions, and copper ion modified titanium dioxide is prepared; the preparation method comprises the following steps: reacting formaldehyde with urea to prepare urea formaldehyde, taking potassium chloride as a coating and urea formaldehyde as a coating layer, and granulating by using a disc granulator to prepare potash fertilizer particles; and uniformly mixing the potash fertilizer particles and the waste liquid treatment liquid to prepare the erythromycin thiocyanate waste liquid fertilizer. According to the technology for preparing the liquid fertilizer from the erythromycin thiocyanate waste liquid, the removal rate of erythromycin thiocyanate and thiocyanic acid in the erythromycin thiocyanate waste liquid is high, and the liquid fertilizer has good slow release performance, environment friendliness and high fertilizer supply capacity.

The application discloses an energy-saving and recycling erythromycin thiocyanate wastewater treatment method and system, which comprises the following steps: firstly pretreating high-concentration erythromycin thiocyanate wastewater; adding an oxidizing agent to effluent water after the first pretreatment and evaporating and concentrating; carrying out anaerobic ammonia oxidation treatment on condensate generated in the evaporation and concentration; mixing mother liquor generated in the evaporation and concentration with low-concentration erythromycin thiocyanate wastewater and secondarily pretreating the mixed wastewater; mixing effluent water after the secondary pretreatment with effluent water after the anaerobic ammonia oxidation treatment and carrying out hydrolytic acidification treatment on the mixed effluent water; sequentially carrying out anaerobic treatment, advanced biochemical treatment and advanced catalytic oxidation treatment on effluent water after the hydrolytic acidification treatment, and discharging the effluent water up to the standard. The application combines the oxidation process with the evaporation process, simultaneously and efficiently removes erythromycin titer and thiocyanate, and eliminates the inhibition of the anaerobic biological process.

The invention provides a sustained-release erythromycin thiocyanate soluble powder and a preparation method thereof, belonging to the technical field of veterinary drug preparations; the preparation method comprises gelatin amination, chitosan carboxymethylation, preparation of modified chitosan, coating and mixing steps; in the coating, erythromycin thiocyanate, glycerol and deionized water are mixed, the temperature is raised to 63-67 DEG C for stirring, and a mixed solution 1 is prepared after the stirring is completed; the modified chitosan and an acetic acid solution are mixed, and the mixed solution 2 is uniformly stirred to prepare a mixed solution; the mixed solution 2 is added to the mixed solution 1, sucrose stearate is added after the stirring is uniform, ultrasonic treatment is performed, and then a functional agent is added, and ultrasonic treatment is performed again, and after the ultrasonic treatment is completed, the mixture is stirred for reaction, and after the reaction is completed, the mixture is filtered, washed and dried to prepare sustained-release erythromycin thiocyanate particles; the product prepared by the method of the invention avoids adding a large amount of acidic reagents, has excellent sustained-release performance, is stable in the acidic environment of gastric juice, and has good drug efficacy.

The invention provides a method for measuring the content of trimethylchlorosilane, and relates to the field of chemical engineering, and the specific method is as follows: preparing a trimethylchlorosilane contrast solution and a test solution, detecting by adopting a gas chromatographic method, and calculating the content by using an external standard method. The method is characterized in that a capillary chromatographic column taking 6%-cyanopropyl phenyl-94%-polydimethylsiloxane as a stationary phase is adopted, n-heptane is taken as a solvent, carrier gas is nitrogen, and effective separation of trimethylchlorosilane and impurities is realized through an optimized gradient heating program. The method is high in precision (RSD is less than or equal to 2%), good in accuracy (average recovery rate is 99.6%), excellent in linear relation (r is equal to 1.000), simple and convenient to operate and free of derivatization step, and is suitable for efficient and reliable determination of trimethylchlorosilane raw materials and residual solvents thereof in drugs (such as erythromycin thiocyanate).

The invention belongs to the field of bio-pharmaceutical post-treatment, and particularly relates to a solid fuel prepared from erythromycin thiocyanate fungus residues as well as a preparation method and application of the solid fuel. The invention provides a solid fuel prepared from erythromycin thiocyanate residues, which is characterized in that the erythromycin thiocyanate residues are subjected to flocculation, filter pressing and secondary drying to obtain a dry material with the water content of 25-35%, and the dry material is prepared into low-temperature solid fuel particles through solid fuel equipment. The prepared fuel particles have the length of 20-100 mm, the diameter of 6 mm, the water content of 14-20% and the calorific value of 3500-5000 kilocalories, and can be used for solid oxide fuel cells, fixed power generation and cogeneration. The environment pollution can be reduced, the value can be extracted from the waste, the cyclic utilization of resources is realized, the recycling of the antibiotic waste is further promoted, and the prospect is good.