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Preparation method of Ca2YREF7@TiO2 nanocomposite powder for inhibiting bacteria and cancer

A nano-composite and nano-particle technology, applied in antibacterial drugs, nano-technology, nano-drugs and other directions, can solve the problems of reduced up-conversion efficiency, lengthened production cycle, cumbersome preparation process, etc., to achieve high crystallinity, uniform particle size, Good monodispersity effect

Active Publication Date: 2015-12-30
梁春永
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: provide Ca 2 YREF 7 TiO 2 A method for preparing nanocomposite powder, which is a two-step hydrothermal synthesis of titanium dioxide-coated rare earth ion-doped yttrium-calcium fluoride composite nanopowder, which overcomes the shortcomings of the existing methods for preparing up-conversion titanium dioxide composite powder Defects of reduced up-conversion efficiency, cumbersome preparation process, longer production cycle and increased cost

Method used

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  • Preparation method of Ca2YREF7@TiO2 nanocomposite powder for inhibiting bacteria and cancer
  • Preparation method of Ca2YREF7@TiO2 nanocomposite powder for inhibiting bacteria and cancer
  • Preparation method of Ca2YREF7@TiO2 nanocomposite powder for inhibiting bacteria and cancer

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Experimental program
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Embodiment 1-9

[0046] The present embodiment is Ca 2 wxya 7 TiO 2 The preparation method of nanocomposite powder, the steps are as follows:

[0047] The first step is to prepare up-conversion nanoparticle powder doped with yttrium calcium fluoride by rare earth ions:

[0048] (1) The chloride of Tm, the chloride of Yb and the chloride of Y, CaCl 2 , PVP is added to deionized water, and after fully stirring, solution A is obtained, wherein the molar concentration of chloride of Tm is 1×10 -5 mol / mL, the molar concentration of chloride of Yb is 5×10 -4 The molar concentration of chloride in mol / mL and Y is 2×10 -3 mol / mL, CaCl 2 The concentration of PVP is 8.88g / L, and the concentration of PVP is 1g / L;

[0049] (2) NH 4 F was dissolved in deionized water to obtain a solution B with a concentration of 51.8g / L;

[0050] (3) Add the above solution B dropwise to the solution A, and fully stir for 2 hours to obtain a mixed reaction system C, wherein the volume ratio of the solution B to th...

Embodiment 10-18

[0093] The molar concentration of chloride divided by the Tm used is 6.5×10 -6 mol / mL, the molar concentration of chloride of Yb is 5×10 -4 The molar concentration of chloride in mol / mL and Y is 1.99×10 -3 Except mol / mL, other is the same as embodiment 1-9.

[0094] Table 2 has listed the Ca that is used for antibacterial tumor suppression that above-mentioned embodiment makes 2 YREF 7 TiO 2 Some relevant influencing factors and parameters of beneficial effects of nanocomposite powder.

[0095] Table 2. Some relevant influence factors and the parameters of beneficial effects in embodiment 10-18

[0096]

Embodiment 19-27

[0098] The molar concentration of chloride divided by the Tm used is 1.1×10 -6 mol / mL, the molar concentration of chloride of Yb is 5×10 -4 The molar concentration of chloride in mol / mL and Y is 1.989×10 -3 Except mol / mL, other is the same as embodiment 1-9.

[0099] Table 3 has listed the Ca that is used for antibacterial tumor suppression that above-mentioned embodiment makes 2 YREF 7 TiO 2 Some relevant influencing factors and parameters of beneficial effects of nanocomposite powder.

[0100] Table 3. Some relevant influence factors and the parameters of beneficial effects in embodiment 19-27

[0101]

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Abstract

The invention discloses a preparation method of Ca2YREF7@TiO2 nanocomposite powder for inhibiting bacteria and cancer, relates to an antitumor medicament, in particular to a method of synthesizing titanium dioxide-coated rare earth ion-doped yttrium calcium fluoride composite nanopowder by a two-step hydrothermal method. The method comprises the following steps of preparing rare earth ion-doped yttrium calcium fluoride upconversion nanoparticle powder; preparing Ca2YREF7@TiO2 nanocomposite powder with a core-shell structure. According to the preparation method disclosed by the invention, the defects that the upconversion efficiency is reduced, a preparation process is troublesome, the production period is prolonged, and the cost is increased existing in the method of preparing upconversion titanium dioxide composite powder in the prior art are overcome.

Description

technical field [0001] The technical scheme of the present invention relates to antineoplastic drugs, specifically Ca 2 YREF 7 TiO 2 Preparation method of nanocomposite powder. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that threaten human health. At present, the treatment of malignant tumors mainly adopts methods such as radiotherapy, chemotherapy and surgical resection, which have large side effects and poor curative effect. Therefore, the development of new methods and new technologies for the diagnosis and treatment of cancer has become a topic of concern to the world. Among many new diagnosis and treatment methods, photodynamic therapy (photodynamic therapy, PDT) is a new and effective method for treating tumors. A photodynamic reaction occurs, and intermediate active substances mainly reactive oxygen species (reactive oxygen species, ROS) are produced to kill tumor cells. The biological mechanism of PDT is based on...

Claims

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Application Information

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IPC IPC(8): A61K41/00B82Y40/00B82Y5/00A61P35/00A61P31/04
Inventor 梁春永
Owner 梁春永
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