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A method for extracting active ingredients from Coptidis rhizome and application of the extract

An effective ingredient, Coptis chinensis technology, applied in the field of extracting active ingredients from Coptis chinensis, can solve the problems of limiting the speed of new drug research and development, and the speed of new drug research and development cannot keep up, and achieves stable activity, good color, and good effect.

Active Publication Date: 2019-03-15
杨丽敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research and development cycle and difficulty of antimalarial drugs greatly limit the speed of research and development of new drugs. The speed of research and development of new drugs cannot keep up with the speed of drug resistance. There is an urgent need to strengthen the research and development of antimalarial drugs

Method used

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  • A method for extracting active ingredients from Coptidis rhizome and application of the extract
  • A method for extracting active ingredients from Coptidis rhizome and application of the extract
  • A method for extracting active ingredients from Coptidis rhizome and application of the extract

Examples

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Effect test

Embodiment 1

[0018] Embodiment 1: A method for extracting active ingredients from Coptidis Rhizoma includes the following steps: (1) select Coptidis Rhizome according to the national standard of Chinese medicinal materials, and grind Coptidis Rhizoma into powder; Carry out a low-temperature water extraction, that is, soak the crushed Coptis chinensis in pure water for 4-6 hours at a temperature of 4°C-20°C, and freeze it at -30°C--25°C until it is frozen solid, and the frozen solid refers to freezing into ice cubes , and then thaw naturally, pour out the infusion, and filter to obtain a low-temperature water extract; (3) freeze-dry the first-time low-temperature water extract to obtain a water-extract dry powder, which is a finished product.

Embodiment 2

[0019] Embodiment 2: A method for extracting active ingredients from Coptidis Rhizoma includes the following steps: (1) select Coptidis Rhizome according to the national standard of Chinese medicinal materials, and pulverize Coptidis Rhizoma into powder; Carry out a low-temperature water extraction, that is, soak the crushed Coptis chinensis in pure water for 4-6 hours at a temperature of 4°C-20°C, and freeze it at -30°C--25°C until it is frozen solid, and the frozen solid refers to freezing into ice cubes , then thaw naturally, pour out the infusion, and filter to obtain a low-temperature water extraction; (3) Second low-temperature water extraction: after the first low-temperature water extraction in step (2), the obtained medicinal residues are subjected to a second low-temperature water extraction, which is about Step (2) Soak the medicinal dregs in pure water so that the medicinal dregs are fully dissolved in pure water, and then freeze at -30°C—-25°C until solidified. The...

Embodiment 3

[0020] Embodiment 3: A method for extracting active ingredients from Coptidis Rhizoma includes the following steps: (1) select Coptidis Rhizome according to the national standard of Chinese medicinal materials, and grind Coptidis Rhizoma into powder; Carry out a low-temperature water extraction, that is, soak the crushed Coptis chinensis in pure water for 4-6 hours at a temperature of 4°C-20°C, and freeze it at -30°C--25°C until it is frozen solid, and the frozen solid refers to freezing into ice cubes , then thaw naturally, pour out the infusion, and filter to obtain a low-temperature water extraction; (3) Second low-temperature water extraction: after the first low-temperature water extraction in step (2), the obtained medicinal residues are subjected to a second low-temperature water extraction, which is about Step (2) Soak the medicinal dregs in pure water so that the medicinal dregs are fully dissolved in pure water, and then freeze at -30°C—-25°C until solidified. The sol...

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Abstract

The invention discloses a method for extracting active ingredients from coptis root and application of extract. The method includes the following steps: (1), smashing the coptis root into powder; (2), performing first-time low-temperature water extraction to obtain first-time low-temperature water extract; (3), freezing and drying the first-time low-temperature water extract to obtain water-extraction dry powder so as to obtain the active ingredients. The method and the application have the advantages that the method is simple, convenient, low in cost, environment friendly and nontoxic, all substances, soluble in water, in the coptis root can be extracted effectively, active ingredients of the extract are extremely easy to absorb and high in stable activity, and protein and polysaccharide in the coptis root are not damaged in the process of hydrolysis; the extract obtained by the method is good in color, high in water solubility and activity, little in dosage, good in effect and high in yield; the method is easy for industrial production and free of waste of raw materials, and one-drug multi-purpose effect can be realized; the extract is high in stability when being stored solely, easy for storage and convenient to use.

Description

Technical field: [0001] The invention relates to a method for extracting active ingredients of medicines, in particular to a method for extracting active ingredients from Coptidis Rhizoma and the use of the extract. Background technique: [0002] There are following deficiencies in the extraction method of traditional Chinese medicine preparation at present, (1) some substances are destroyed soon after heating, and irreversible reactions occur, and become colloids, which are difficult to dissolve and can only be dissolved with organic matter; (2) the medicinal materials extracted by the existing process , low degree of hydrolysis, low activity, large dosage, ineffective effect and low yield. [0003] In tropical and subtropical developing countries, malaria is one of the most serious infectious diseases. According to the World Health Organization, there were 243 million clinical malaria cases and 863,000 deaths from malaria in the world in 2008. Chloroquine has been the fir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P33/06
CPCY02A50/30
Inventor 杨丽敏
Owner 杨丽敏
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