Traditional Chinese medicinal composition for treating sepsis myocardial dysfunction

A composition and heart function technology, applied in the direction of drug combination, anti-infective drugs, pharmaceutical formulations, etc., to achieve the effects of protecting endothelial function, improving hemodynamics, and improving heart function

Active Publication Date: 2016-02-03
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no effective drug for the treatment of septic cardiac dysfunction in clinical practice.

Method used

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  • Traditional Chinese medicinal composition for treating sepsis myocardial dysfunction
  • Traditional Chinese medicinal composition for treating sepsis myocardial dysfunction
  • Traditional Chinese medicinal composition for treating sepsis myocardial dysfunction

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Experimental program
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Effect test

preparation example Construction

[0021] A preparation method of a traditional Chinese medicine composition for treating sepsis heart dysfunction, comprising the steps of:

[0022] 1) Take cassia twig, salvia miltiorrhiza, heterophylla and raw rhubarb, add water to decoct, filter and combine the filtrate, and concentrate to a concentrate;

[0023] 2) Add ethanol to the concentrated solution and let it stand below 10°C for at least 8 hours;

[0024] 3) recovering ethanol, concentrating to a relative density of 1.10-1.20 to obtain an extract;

[0025] 4) take Suhe balsam and artificial bezoar, pulverize to obtain medicinal powder;

[0026] 5) mixing the extract and powder evenly, drying, adding acceptable pharmaceutical excipients to prepare an oral agent;

[0027] Wherein, the proportioning of cassia twig, salvia miltiorrhiza, Radix Pseudostellariae, raw rhubarb, Suhe balsam and artificial bezoar is as above.

Embodiment 1

[0029] Composition of raw materials: 15 parts of cassia twig, 15 parts of salvia miltiorrhiza, 20 parts of heterophylla, 20 parts of raw rhubarb, 1 part of styrax, and 1 part of artificial bezoar.

[0030] Preparation:

[0031] 1) Weigh cinnamon sticks, salvia miltiorrhiza, heterophylla and raw rhubarb according to the proportion, add water to decoct, combine the filtrates and concentrate to obtain a concentrate;

[0032] 2) Add ethanol to the concentrated solution, let stand below 10°C for at least 8 hours, then filter, recover the ethanol, concentrate to a relative density of 1.10-1.20, and obtain an extract;

[0033] 3) Take the styrax balsam and artificial bezoar according to the proportioning ratio, and pulverize them to below 120 mesh to obtain the medicinal powder;

[0034] Mix the extract and powder evenly, dry, pulverize, pass through a 120-mesh sieve, and add pharmaceutically acceptable excipients to form granules.

Embodiment 2

[0036] Composition of raw materials: 14 parts of cassia twig, 16 parts of salvia miltiorrhiza, 22 parts of heterophylla, 17 parts of raw rhubarb, 0.9 part of styrax, and 1.2 parts of artificial bezoar.

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PUM

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Abstract

The invention discloses a medicine for treating sepsis myocardial dysfunction. The medicine consists of an active ingredient and a pharmaceutically acceptable excipient, wherein the active ingredient is prepared from the following raw materials: cassia twig, radix salviae miltiorrhizae, radix pseudostellariae, styrax ester, calculus bovis factitius and radix et rhizoma rhei. The traditional Chinese medicinal composition disclosed by the invention, which is prepared from the active ingredient and the excipient together, is capable of effectively improving the cardiac function of patients with sepsis myocardial dysfunction and reducing a death rate, a myocardial injury marker and an inflammatory mediator, and the traditional Chinese medicinal composition is free from an adverse reaction. The medicine fills a gap in the therapeutic field.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating sepsis heart dysfunction. Background technique [0002] Sepsis is a systemic inflammatory response syndrome caused by infection. According to statistics, there are more than 18 million cases of sepsis in the world every year, and the rate is increasing at a rate of 1.5% to 8.0% per year. Sepsis is a dangerous condition with a high fatality rate. About 14,000 people worldwide die of sepsis every day, and it is the main cause of death of non-cardiac patients in the intensive care unit. Despite significant progress in anti-infection therapy and organ function support technology, the current mortality rate of sepsis is still as high as 30% to 70%, and the high cost of treatment and consumption of medical resources seriously endanger human health. [0003] Sepsis cardiac dysfunction (sepsis cardiocardial dysfunction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61P31/00A61P9/00A61P9/14A61K35/413
Inventor 毛帅郭力恒张敏州
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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