Elimination agent for oral cavity biofilm and oral cavity composition

A technology of biofilm and composition, which is applied in the fields of oral care, cosmetic preparations, medical science, etc. It can solve the problems of no biofilm removal effect, reduce the astringency of zinc salt, etc., and achieve a good sense of use, excellent effect, Effect of suppressing bitterness

Active Publication Date: 2016-02-24
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, Patent Document 2 (Japanese Patent Publication No. 2008-519043) discloses a method of using an alkali metal salt or an ammonium salt of an alkyl sulfoacetate and a water-soluble zinc salt in combination, but the alkyl sulfoacetate is used for Compounds that reduce the astringent properties of zinc salts did not show biofilm removal effects
Furthermore, Patent Document 3 (Japanese Patent Laid-Open No. 9-508120) discloses a toothpaste containing sodium lauryl sulfoacetate as an oral composition for reducing irritation to the oral mucosa, but does not refer to improving the biofilm removal effect

Method used

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  • Elimination agent for oral cavity biofilm and oral cavity composition
  • Elimination agent for oral cavity biofilm and oral cavity composition
  • Elimination agent for oral cavity biofilm and oral cavity composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0101] [Example 1, Comparative Example 1]

[0102] Dentifrice compositions with the components shown in Tables 1 and 2 were prepared according to the methods shown below, and evaluated by the following methods. The results are recorded in Tables 1 and 2 together.

[0103] The preparation method of dentifrice composition:

[0104] First, mix the polycondensed phosphate of the component (B-1) and the water-soluble components used in purified water containing a thickener such as sorbitol liquid at room temperature, and then further mix a binder and a stabilizer, and carry out the process with a disperser. dispersion. Add the dispersion liquid and the grinding agent to the kneader and mix, then add the fragrance and (A) component α-olefin sulfonate. The inside of the kneader was depressurized to about 5 kPa to defoam, and further mixing was continued to obtain a dentifrice composition. In addition, the composition of the comparative example was prepared according to the above-...

Embodiment II

[0167] [Example II, Comparative Example II]

[0168] Prepare the oral composition of the components shown in Tables 3 to 6 according to the method shown below (Tables 3 and 4 are dentifrice compositions, and Tables 5 and 6 are mouthwash compositions), using the same method as above Make an evaluation. The results are also described in Tables 3-6.

[0169] In addition, sensory evaluation was performed for the presence or absence of bitterness and the quality of foaming of the mouthwash composition by the following methods.

[0170] 10 mL of mouthwash was contained in the mouth and swished for 20 seconds, and the presence or absence of bitterness at the time of gargling was judged based on the above scoring criteria. Evaluation was performed based on the average of 6 evaluators based on the above evaluation criteria.

[0171] The preparation method of dentifrice composition:

[0172] First, water-soluble components such as sodium fluoride are mixed with purified water contai...

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PUM

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Abstract

Provided are: an elimination agent that is for oral cavity biofilms and that comprises (A) an [alpha]-olefin sulfonate and (B) a condensed phosphate (B-1) and/or an amphoteric surfactant (B-2); and an oral cavity composition comprising component (A) and component (B) and having a high elimination effect with respect to oral cavity biofilms.

Description

technical field [0001] The present invention relates to an oral biofilm removing agent and a composition for oral cavity that chemically and efficiently remove biofilm that is the cause of dental caries. Background technique [0002] Conventionally, techniques for removing plaque (tartar) in dentifrices include physical removal by cleaning agents such as abrasives, biochemical removal by enzymes, and the like. [0003] When removing with a cleaning agent, it is necessary to increase the amount of the abrasive and increase the hardness in order to exert its effect, but as the abrasive force increases, there is a possibility that harmfulness and irritation such as damage to teeth and gums may easily occur. On the other hand, in order to stabilize the mixed enzyme, it is necessary to use various stabilizers in combination, which may affect the usability such as foaming and taste. [0004] In addition, in recent years, if the plaque can be captured as a biofilm and the biofilm ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/24A61K8/44A61Q11/00
CPCA61K8/345A61K8/416A61K8/442A61K8/466A61K8/4946A61Q11/00A61K8/24A61K8/4926
Inventor 山本幸司石川悠湖山口翼青木优子
Owner LION CORP
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