Composition prepared from saikosaponin, the use and the preparation method thereof

A technology of saikosaponin and composition, which is applied in the field of saikosaponin treatment and prevention of virus infection, can solve the problems of drug side effects and high price, and achieve the effect of improving bioavailability and easy epidemic prevention work

Inactive Publication Date: 2016-02-24
KAOHSIUNG MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although such an antiviral strategy has benefited many hepatitis C patients, many problems have emerged, such as drug side effects and high prices.

Method used

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  • Composition prepared from saikosaponin, the use and the preparation method thereof
  • Composition prepared from saikosaponin, the use and the preparation method thereof
  • Composition prepared from saikosaponin, the use and the preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0072] Preparation of SSb2 nanoformulations

[0073] The dispersion and blending reaction of SSb2 can be carried out by emulsion solvent diffusion method (emulsionsolventdiffusionmethod), and the nano-sized preparation of SSb2 can be prepared. This process can be performed with a variety of high molecular weight polymers, such as tri-group polymers ( polymer), polyvinylalcohol (polyvinylalcohol, PVA), polyvinylpyrrolidone (polyvinylpyrrolidone, PVP), etc. According to the solubility characteristics of SSb2, and taking polyvinylpyrrolidone as an example, this process first dissolves SSb2 with an appropriate amount of ethanol to make a 1mg / ml solution, dissolves polyvinylpyrrolidone with an appropriate amount of pure water to prepare a 35% aqueous solution, and then injects the SSb2 solution into polyethylene In the pyrrolidone aqueous solution, ultrasonic waves are used to promote the dispersion and blending reaction of SSb2 and polyvinylpyrrolidone, and then the organic solv...

Embodiment

[0083] 1. A method for preventing or treating viral infection, wherein the virus is selected from the group consisting of hepatitis C virus, measles virus, respiratory fusion virus, vesicular stomatitis virus, dengue virus and non-enveloped virus, The method includes the step of administering to a subject suffering from the infection a pharmaceutical composition comprising saikosaponin.

[0084] 2. The method as described in embodiment 1, wherein the saikosaponin is obtained from Bupleurum alcohol extract.

[0085] 3. The method according to embodiment 1 or 2, wherein the saikosaponin is at least one selected from the group consisting of SSa, SSb2, SSc and SSd.

[0086] 4. The method as described in the previous embodiment, wherein the saikosaponin is derived from Bupleurumkaoi.

[0087] 5. The method as described in the preceding embodiments, wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.

[0088] 6. The method as described i...

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Abstract

This invention relates to a pharmaceutical composition having saikosaponin as a main component, the use of the pharmaceutical composition, as well as the preparation method thereof, wherein the pharmaceutical composition is used to prevent or treat the infection of one virus selected from the hepatitis C virus, the measles virus, the respiratory syncytial virus, the vesicular stomatitis virus, the dengue virus, and the non-enveloped viruses.

Description

technical field [0001] The present invention relates to the use of saikosaponin for treating and preventing viral infection, a pharmaceutical composition containing saikosaponin and a method for preparing the pharmaceutical composition. Background technique [0002] There are currently about 170 million people in the world (accounting for 2% of the global population) infected with hepatitis C virus (HCV) and suffering from liver diseases (hepatitis, cirrhosis and liver cancer), which is a serious global health and medical burden . At present, there is no preventive vaccine for hepatitis C, and the existing clinical treatment drug interferon-α (interferon-alpha, IFN-α) + ribavirin (ribavirin) has no therapeutic effect on the most common genotype type 1 Ideal (about 50% cure rate) and side effects, and requires huge medical funds, resulting in many patients can not afford the course of treatment and economic burden. Although the U.S. Food and Drug Administration (FDA) approv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P31/12
CPCY02A50/30
Inventor 林俊清林良宗克里斯多福·D.·理查德森颜铭宏钟決窈
Owner KAOHSIUNG MEDICAL UNIVERSITY
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