A kind of drug-loaded hydrogel coating and preparation method and application thereof

A kind of aluminum oxide hydrogel and gel technology, applied in coating, medical science, tissue regeneration, etc., can solve the problems of delayed infection and unsatisfactory antibacterial effect, and achieve the effect of preventing delayed infection

Active Publication Date: 2018-06-15
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nowadays, implant materials are often used in medicine to repair damaged tissues, but it is necessary to prevent the occurrence of tissue site infection during tissue repair. The antibacterial effect of commonly used tissue repair materials is not ideal, and often causes delayed infection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:

[0044] (1) Add 2.5 g of aluminum isopropoxide to 50 mL of deionized water, and stir the white precipitate at 80°C for 15 minutes to obtain a dispersion. The dispersion is ultrasonically treated for 2 hours and cooled to room temperature to obtain alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 2%.

[0045] (2) Dissolve 10 mg of anti-infective penicillin in 1 mL of Tris-hydrochloric acid buffer (concentration 0.05M) with pH=7.4 to obtain an anti-infective solution, and combine 100 μL of the alumina hydrogel obtained in step (1) with 50 μL of anti-infection The drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and coat it for 5 times, and then put it in a vacuum to dry...

Embodiment 2

[0047] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:

[0048] (1) Add 2.5g of aluminum isopropoxide to 25mL of deionized water, stir the white precipitate at 80°C for 30min to obtain a dispersion, then ultrasonically treat the dispersion for 1h and cool to room temperature to obtain an alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 3%.

[0049] (2) Dissolve 10 mg of the anti-infective drug erythromycin in 2 mL of pH=7.4 Tris-hydrochloric acid buffer (concentration 0.05M) to obtain an anti-infective drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 80 μL The anti-infective drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and apply 7 times to coat it evenly. Drying in a vacuum drying oven a...

Embodiment 3

[0051] In this embodiment, the preparation of the drug-loaded hydrogel coating by the following method specifically includes the following steps:

[0052] (1) Add 2.5g of aluminum isopropoxide to 75mL of deionized water, stir the white precipitate at 80°C for 20min to obtain a dispersion, then ultrasonically treat the dispersion for 3h and cool to room temperature to obtain alumina hydrogel (Al 2 O 3 ·H 2 O), where the mass content of aluminum is 1%.

[0053] (2) Dissolve 10 mg of the anti-infective drug levofloxacin in 3 mL of pH=7.4 Tris-hydrochloric acid buffer (concentration 0.05M) to obtain an anti-infective drug solution, and combine 100 μL of the alumina hydrogel obtained in step (1) with 30 μL of anti-infection The drug solution was mixed uniformly in a 1.5mL glass tube, and then 50μL of the mixed solution was taken on a glass slide (2cm×2cm size) with a pipette, and the Meyer rod was used to repeatedly press and coat it for 3 times, and then place it in a vacuum to dry. Dr...

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Abstract

The invention provides a medicine-carrying aquogel coating and a preparation method and application thereof. Alumina aquogel serves as a coating substrate and carries anti-infection medicine, and the nanometer medicine-carrying aquogel coating is obtained; due to the characteristics that alumina aquogel is not degraded and is slowly absorbed by human bodies, the anti-infection medicine carried by the medicine-carrying coating can be stored in the coating all the time, and the anti-infection effect of the coating can be achieved continuously; when the coating is applied to an implant material, a composite implant body is obtained and implanted into a human body, and chronic infection especially the chronic infection caused by the implant material can be effectively stopped when damaged parts are repaired.

Description

Technical field [0001] The invention belongs to the field of hydrogel preparation, and relates to a drug-loaded hydrogel coating and a preparation method and application thereof. Background technique [0002] Nowadays, implant materials are often used in medicine to repair damaged tissues. However, it is necessary to prevent tissue site infections during tissue repair. The antibacterial effect of commonly used tissue repair materials is not ideal and often causes delayed infections. . The research on medical materials capable of tissue repair has become a hot spot. [0003] Hydrogel is a multi-element system composed of polymers and other materials through a three-dimensional cross-linked network structure and media. Because of its stable properties, it can quickly respond to small changes in the environment. As a new type of biomedical material, it has attracted many researchers’ attention. attention. Taking advantage of its good biocompatibility, hydrogels can be used in drug ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/30
CPCA61L27/306A61L27/54A61L2300/104A61L2300/206A61L2300/21A61L2300/216A61L2300/23A61L2300/404A61L2430/02A61L2430/12A61L2430/22A61L2430/24
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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