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Novel application of acetylcysteine

A technology of acetylcysteine ​​and cysteine ​​gel, which is applied in the field of new uses of acetylcysteine, can solve the problems of lack of effective drugs and means for oral ulcer care and treatment, and achieves rich varieties, The effect of blocking the aggravation of ulcers and relieving pain

Inactive Publication Date: 2016-03-23
TIANJIN KUNJIAN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinicians lack effective drugs and methods for the nursing and treatment of oral ulcers in such patients.

Method used

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  • Novel application of acetylcysteine
  • Novel application of acetylcysteine
  • Novel application of acetylcysteine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Cool 75g of purified water to 10°C, pass N during the cooling process 2 When the dissolved oxygen content is less than 2ppm (about 1.7ppm), add 10g acetylcysteine, 0.05g ethylenediaminetetraacetic acid, 0.5g sodium citrate and 0.05g sucralose and stir to mix. During stirring, use a temperature of 10°C , Tong N 2 Dissolved oxygen <2ppm (about 1.7ppm) alkaline solution to adjust the pH value to 6.0, after the acetylcysteine ​​is dissolved, add 0.1g methyl p-hydroxybenzoate and 15g poloxamer (use concentration is 20% (w / v)), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 24 hours, and filter to obtain the acetylcysteine ​​gel.

Embodiment 2

[0041] Cool 70g of purified water to 1°C, pass N during the cooling process 2When the dissolved oxygen content is less than 2ppm (about 1.9ppm), add 30g acetylcysteine, 0.1g sodium metabisulfite and 0.1g sucrose and stir to mix. 2 Dissolved oxygen<2ppm (about 1.9ppm) alkaline solution to adjust the pH value to 7.0, after the acetylcysteine ​​is dissolved, add 0.2g sodium benzoate and 20g poloxamer (use concentration is 10% (w / v )), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 12 hours, and filter to obtain the acetylcysteine ​​gel.

Embodiment 3

[0043] Cool 75g of purified water to 20°C, pass N during the cooling process 2 To dissolved oxygen 2 Dissolved oxygen<2ppm (about 1.8ppm) alkaline solution to adjust the pH value to 5.0, after the acetylcysteine ​​is dissolved, add 1.0g potassium sorbate and 13g poloxamer (use concentration is 25% (w / v)), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 18 hours, add 0.05g of lemon essence to dissolve and filter, and obtain the acetylcysteine ​​gel.

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Abstract

The invention provides novel application of the acetylcysteine; the acetylcysteine is suitable for treating oral ulcer; and an acetylcysteine gel, which is prepared according to the application, simultaneously has medicinal functions of rapidly relieving pain and preventing ulcer, and specifically inhibiting further spread of ulcer in patients receiving radiotherapy, chemotherapy and bone marrow transplantation and promoting wound healing.

Description

technical field [0001] The invention relates to a new application of medicine, especially a new application of acetylcysteine. Background technique [0002] There are about 3.2 million cancer patients in China every year, which has already posed a huge threat to the health of our country. Radiotherapy, chemotherapy, and bone marrow transplantation have become the routine means for patients to fight cancer, and can receive significant therapeutic effects. However, while these methods suppress cancerous cells, they also cause varying degrees of damage to the body's own immune system, accompanied by the occurrence of various infections. As a non-keratinized site, oral mucosal ulcers are the most common complication in patients receiving radiotherapy, especially in patients receiving head radiotherapy, the incidence of oral ulcers is close to 100%. The symptoms of oral ulcers are mainly as follows: mucosal erythema, edema, ulcers, and at the same time the pain is unbearable, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K9/06A61K47/34A61P1/02
CPCA61K31/198A61K9/0053A61K9/06A61K47/10
Inventor 毛慧华邱东旭郝桂彤王月然姜来刘昊川周密
Owner TIANJIN KUNJIAN BIOLOGICAL PHARMA
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