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A radionuclide strontium internal pollution discharge accelerator

A radionuclide and excretion-promoting agent technology, applied in the field of medicine, can solve the problems of liver and kidney damage, calcium loss, major side effects, etc., and achieve the effects of reducing accumulation, preventing calcium loss in bones, and reducing kidney damage.

Inactive Publication Date: 2017-07-07
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The radionuclide strontium is mainly distributed in tissues with more calcium, such as bone, and will participate in bone formation over time. It is deposited in the bone during the osteogenesis process and is difficult to transfer. At present, the domestic radionuclide strontium promotes excretion Among the chelating agents, S106, S186 (acetamidopropene diphosphonic acid, APDA, Chinese medicine Ji Nei Jin, and CTS-EDTA nanoparticles have appeared recently, but the effect of these chelating agents alone is not satisfactory enough) , or the effect of promoting excretion is good but has relatively large side effects, such as calcium loss or greater damage to the liver and kidneys, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of the radionuclide strontium internal pollution expediting agent, at room temperature, add CTS-EDTA nanoparticles, calcium dobesilate, and normal saline to an appropriate amount of potassium dihydrogen phosphate-sodium hydroxide buffer to adjust the pH to After 7, stir again with 360rpm magnetic force until the mixture is homogeneous. The range of nanometer particle size after raw material mixing is 120-130nm.

[0025] Select 5-week-old female experimental mice with a body weight of 20±0.3g.

Embodiment 1

[0033] The mice were set up as parallel samples, and each was injected with 2Ci 15ul once every 5 days 89 SrCl 2 After 6 injections of the solution, 120ul 5mg / ml of the row-promoting agent of the present invention was administered intravenously every 8 hours, and the follow-up treatment was the same as in Comparative Example 1.

[0034] Table 1 shows the content of radioactive strontium in the femur at different time points when the drug was injected and after two injections (DPM / g×10 5 , ±Sn=5)

[0035] when injecting (medicine) 48h 72h Comparative example 1 73.3658 61.3856 54.2933 Comparative example 2 74.2432 32.9475 16.6548 Comparative example 3 74.8984 51.9278 46.7461 Example 1 75.2489 21.4476 2.13294

[0036] Adopt the processing method in comparative example and embodiment, radioactive strontium forms certain deposition amount in the osteogenesis process of mouse, as can be seen from the data of table 1, the radionucl...

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PUM

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Abstract

The invention relates to a chelator for internal contamination of radionuclide strontium. The chelator comprises raw materials in parts by mass as follows: 0.6-0.8 parts of CTS-EDTA nanoparticles, 0.08-0.12 parts of calcium dobesilate, 8-10 parts of normal saline (0.85-0.9wt%) and a proper amount of a monopotassium phosphate-sodium hydroxide buffer solution. The chelator for internal contamination of the radionuclide strontium can effectively chelate the radionuclide strontium in skeletons, intravenous administration is performed twice in a mouse test, the discharge rate of the radionuclide strontium in the skeletons after 3 d is higher than 97%, and the accumulated amount of the radionuclide strontium in the skeletons is greatly decreased; the content of protein in proteinuria caused by the radionuclide is decreased by more than 60%, so that the renal injury is obviously reduced.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a radionuclide internal pollution discharge accelerator. Background technique [0002] With the application and development of nuclear technology, the contamination of radionuclides in the body has become an urgent problem to be solved. The promotion of radionuclide contamination in the body is an important means to prevent the damage of radionuclide internal exposure. [0003] The radionuclide strontium is mainly distributed in tissues with more calcium, such as bone, and will participate in bone formation over time. It is deposited in the bone during the osteogenesis process and is difficult to transfer. At present, the domestic radionuclide strontium promotes excretion Among the chelating agents, S106, S186 (acetamidopropene diphosphonic acid, APDA, Chinese medicine Ji Nei Jin, and CTS-EDTA nanoparticles have appeared recently, but the effect of these chelating agents alone is not sati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K31/185A61K9/10A61P39/02
CPCA61K9/0019A61K9/10A61K31/185A61K31/722A61K47/02A61K2300/00
Inventor 张宁宁建红李进英张佩娟
Owner QINGDAO CENT HOSPITAL
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