Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium or a pharmaceutically acceptable salt thereof in the prevention and treatment of diabetes

A technology of dimethyl propane and diabetes, applied to the use of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium or its pharmaceutically acceptable salt in the prevention and treatment of diabetes areas that can address issues such as inadequate insulin control

Active Publication Date: 2016-04-27
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also due to inadequate insulin control, achieving and maintaining long-term glycemic control with existing medications in T2DM patients is often challenging (MANNINOG.C., SESTIG. Individualized Therapy for Type 2 Diabetes: Clinical Implications

Method used

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  • Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium or a pharmaceutically acceptable salt thereof in the prevention and treatment of diabetes
  • Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium or a pharmaceutically acceptable salt thereof in the prevention and treatment of diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] Female ApoE weighing 18-20 g - / - Mice were kept in an air-conditioned room (22.5±0.5°C, 50±5% humidity) with a light-dark cycle of 12h dark / 12h light, with unrestricted access to food and water.

[0013] Mice were acclimated to the field environment for 1 week before starting the study. At 8 weeks of age, mice were randomly assigned to 5 equally sized groups (n=10). Experimental animals in all groups were fed for 4 months with WESTERNRD(P) feed (Cat 82316) from Special Diets Services (UK). During this 4-month period, mice in different experimental groups received the following treatments:

[0014] Control group – drinking water;

[0015] GBB group – GBB10mg / kg;

[0016] 3-Carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium hydrogen fumarate group – 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium fumarate Hydrogen maleate 17.5mg / kg;

[0017] 3-Carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium phosphate dihydrogen salt group – 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium p...

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Abstract

Use of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium and its pharmaceutically acceptable salts to decrease blood plasma levels of insulin and glucose.

Description

technical field [0001] The present invention relates to 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium or its pharmaceutically acceptable salt for preventing and treating diabetes. Examples of pharmaceutically acceptable salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium are: 3-carboxy-N-ethyl-N,N-dimethylpropan- 1-Ammonium hydrogen fumarate and 3-carboxy-N-ethyl-N,N-dimethylpropan-1-ammonium dihydrogenphosphate. Background technique [0002] It is known that 3-carboxy-N,N,N-trimethylpropan-1-ammonium (GBB) is mainly a bioprecursor of carnitine, a key molecule regulating myocardial energy metabolism. It was initially characterized as a toxic substance that accelerated respiration, causing salivation and lacrimation, pupillary dilation, vasoconstriction and diastolic cardiac arrest (LINNEWEHW. , p.42-53). In later publications, it has been shown that 3-carboxy-N,N,N-trimethylpropan-1-ammonium has very low toxicity (LD 5O 7000 mg / kg, s.c.) (ROTZSCH.W.UberdieToxizita...

Claims

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Application Information

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IPC IPC(8): A61K31/205C07C227/08C07C229/12
CPCA61K31/205
Inventor 马尧伊·达姆布罗瓦海伦娜·奇鲁尔伊瓦尔斯·卡尔温斯埃德加斯·利平斯叶琳娜·马卡罗娃伊尔马斯·斯托南斯伊尔加·米萨内
Owner GRINDEKS
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