A kind of roxithromycin-loaded nanostructure lipid carrier gel and preparation method thereof
A nano-structured lipid and roxithromycin-loaded technology, which is applied in liposome delivery, pharmaceutical formula, liquid delivery, etc., can solve the problems of short residence time and unfavorable conditions, and achieve increased local concentration, delayed evaporation, and increased viscosity. Adjunctive effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0064] ① Roxithromycin nanostructured lipid carrier
[0065] Accurately weigh 1 mg of roxithromycin, 75 mg of glyceryl distearate, 45 mg of caprylic / capric glycerides, and 67 mg of soybean lecithin, dissolve them in 1 mL of ethanol, melt them in a water bath at 75 °C, and use them as the oil phase; Each 80 mg of Tween 80 and F18 was dissolved in 20 mL of water as the water phase. Under magnetic stirring in a constant temperature water bath, slowly add the oil phase to the water phase at a rate of 0.2 mL / min. After all the addition is complete, continue to stir for 30 min, transfer while hot, and ultrasonicate the probe for 90 s at 20% ultrasonic power. Quickly transferred to an ice-water bath to solidify for 20 minutes, and filtered through a 0.22 μm microporous membrane to obtain a roxithromycin nanostructured lipid carrier.
[0066] ② Roxithromycin-loaded nanostructured lipid carrier gel
[0067] Prepare and take by weighing 4g of roxithromycin-loaded nanostructured lipid ...
Embodiment 2
[0069] ① Roxithromycin nanostructured lipid carrier
[0070] Precisely weigh 4 mg of roxithromycin, 45 mg of glyceryl distearate, 30 mg of caprylic / capric macrogol glycerides, and 67 mg of soybean lecithin, dissolve them in 3 mL of ethanol, and melt in a water bath at 75 °C to form an oil phase ; Precisely weigh 38 mg each of Tween 80 and F68, and dissolve them in 10 mL of water to form an aqueous phase. Under magnetic stirring in a constant temperature water bath, slowly add the oil phase to the water phase at a rate of 0.2mL / min. After all the addition is complete, continue to stir for 30 min, quickly transfer to an ice-water bath to solidify for 30 min, and pass through a 0.22 μm microporous filter. Membrane filtration, the roxithromycin nanostructure lipid carrier is prepared.
[0071] ② Roxithromycin-loaded nanostructured lipid carrier gel
[0072] Preparation Weigh 5.5g of roxithromycin-loaded nanostructured lipid carrier freeze-dried powder, dissolve it in 7mL of wate...
Embodiment 3
[0074] ① Roxithromycin nanostructured lipid carrier
[0075] Accurately weigh 7mg of roxithromycin, 60mg of glyceryl monostearate, 60mg of medium-chain triglycerides, and 67mg of soybean lecithin, dissolve them in 5mL of ethanol, melt in a water bath at 75°C, and form an oil phase; Each 150mg of Tween 80 and HS15 is dissolved in the prescribed amount of water to form an aqueous phase. Under magnetic stirring in a constant temperature water bath, slowly add the oil phase to the water phase at a rate of 0.2mL / min. After all the addition is complete, continue to stir for 30 min, quickly transfer to an ice-water bath to solidify for 10 min, and pass through a 0.22 μm microporous filter. Membrane filtration, the roxithromycin nanostructure lipid carrier is prepared.
[0076] ② Roxithromycin-loaded nanostructured lipid carrier gel
[0077] Prepare and take by weighing 7g of roxithromycin-loaded nanostructured lipid carrier freeze-dried powder, dissolve with 7mL water to obtain the...
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com