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Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout

A technology of celery seed extract and hyperuricemia, which is applied in the fields of natural medicinal chemistry and medicine, can solve the problems of pharmacological action mechanism and research that have not yet been carried out, and achieve significant inhibitory activity, anti-hyperuricemia and anti-gout. Effect

Inactive Publication Date: 2016-05-04
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent ZL20100615591.2 protects the oral liquid or soft capsule preparation of ethanol extract of celery seed for the treatment of gout, but no related pharmacological mechanism research has been carried out

Method used

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  • Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout
  • Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout
  • Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of celery seed extract:

[0037] 20 kg of dried celery seeds were added with 8 times the amount of 70% (V / V) ethanol to heat and extract twice, each time for 2 hours; the extracts were combined, concentrated under reduced pressure at 65° C., and dried to obtain 3.2 kg of celery seed extract.

Embodiment 2

[0039] Effects of celery seed extract on hyperuricemia in mice induced by oxonic acid potassium salt:

[0040] Get the celery seed extract of embodiment 1, three dosage groups of high, middle and low are respectively 200,100,50mg / kg, are mixed with the suspension of 10,5,2.5mg / mL concentration with pure water; Purine tablets are prepared into a suspension with a concentration of 2 mg / mL in pure water.

[0041] Take 72 male ICR mice of 21-24g, and randomly divide them into 6 groups according to body weight: normal control group; model control group; positive control group of allopurinol tablet 40mg / kg; celery seed extract 200, 100, 50mg / kg Group. Except for the positive control allopurinol tablet, which was intragastrically administered once on the day of the experiment, the animals in the other groups were intragastrically administered once a day according to the dose, for 3 consecutive days. On the 2nd day, the mice were fasted overnight (12h), and in the morning of the nex...

Embodiment 3

[0050] Effects of celery seed extract on paw swelling in mice induced by carrageenan:

[0051] The celery seed extract of embodiment 1, three dosage groups of high, middle and low are respectively 200,100,50mg / kg, are mixed with the suspension of 10,5,2.5mg / mL concentration with pure water; Mexin enteric-coated tablets are prepared into a suspension with a concentration of 0.5 mg / mL in pure water.

[0052] Male ICR mice of 19-21 g were selected and randomly divided into 5 groups according to body weight: control group; positive control groups of indomethacin tablet 10 mg / kg, celery seed extract 200, 100, 50 mg / kg, 12 in each group. Except for the indomethacin tablet which was administered by intragastric administration only once on the day of the experiment, the animals in the other groups were intragastrically administered once a day according to the dose for 3 consecutive days, and the control group was given 20mL / kg.bw of pure water. 30 minutes after the last administratio...

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Abstract

The invention relates to application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout and further provides medicine or health-care food for treating hyperuricemia and gout. Celery seed extract serves as the active constituent, and an appropriate number of medical carriers or auxiliary constituents are added, so that a preparation is obtained. The medicine for health-care food is simple in preparation process, the celery seed extract can obviously lower serum uric acid of model mice suffering from hyperuricemia caused by oteracil potassium salt, lower the activity of xanthine oxidase to different degrees, achieve an obvious inhibition effect on arthritis of the mice, prevent and treat hyperuricemia or gout and be applied to preparation of the medicine or health-care food for resisting to hyperuricemia and gout.

Description

technical field [0001] The present invention relates to the technical fields of natural medicinal chemistry and medicine, specifically, the application of a celery seed extract in the preparation of anti-hyperuricemia and anti-gout drugs, and its application in the preparation of anti-hyperuricemia and anti-gout drugs. Nutraceutical application of gout drugs. Background technique [0002] In the records of traditional Chinese medicine, gout belongs to the category of "arthralgia syndrome". Symptoms such as fever. Gout is a group of clinical syndromes characterized by long-term purine metabolism disorder, continuous increase of blood uric acid leads to deposition of urate crystals, and tissue damage such as characteristic chronic arthritis and joint deformity. In recent years, with the continuous improvement of people's living standards, the diet structure has also changed. Excessive intake of purine and protein has made the incidence of gout in my country increase year by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A23L33/105A61P19/06A61P19/02
CPCA61K36/23A23V2002/00A61K2236/333A61K2236/39A61K2236/51A61K2236/53A23V2200/30A23V2250/21
Inventor 陈纪军杨通华黄晓燕马云保张雪梅沈勇耿长安卢承杰
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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