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Production process for radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation

A production process and preparation technology, which is applied in the field of production process of Fuguigutong preparation, can solve the problem that the effective components of Epimedium are difficult to detect, icariin is difficult to detect, and the clinical curative effect of Fuguigutong preparation is not ideal, etc. problem, to achieve significant drug efficacy, good clinical efficacy, and improve drug efficacy

Inactive Publication Date: 2016-05-04
GUIZHOU HUAANTANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found in the course of the research that the active ingredients of Epimedium are not easy to detect in the Fuguigutong preparation prepared by the existing extraction process, especially the icariin.
The clinical curative effect of Fuguigutong preparation is not ideal enough

Method used

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  • Production process for radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation
  • Production process for radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation
  • Production process for radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Recipe: 266g Aconite, 133g Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0076] Process: take Epimedium, add 10 times the amount of 80% ethanol solution to reflux extraction for 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, and set aside; add 8 times the amount of water to extract the filter residue for 2 times , each time for 2 hours, filter, combine the filtrates, concentrate into a concentrated solution, combine with the above-mentioned alcohol extract, and concentrate to an extract with a relative density of 1.10-1.20 when concentrated to 50-60 ° C, to obtain Epimedium extract, for subsequent use Take Angelica, add 10 times the amount of water and decoct 3 times, 2 hours each time, combine the decoction, filter, concentrate until the ratio of volume per milliliter to medicinal material per gram is 1:1, filte...

Embodiment 2

[0084] Recipe: 266g Aconite, 133g Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0085] Process: take Epimedium, add 10 times the amount of 80% ethanol solution to reflux extraction for 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, and set aside; add 8 times the amount of water to extract the filter residue for 2 times , each time for 2 hours, filter, combine the filtrates, concentrate into a concentrated solution, combine with the above-mentioned alcohol extract, and concentrate to an extract with a relative density of 1.10-1.20 when concentrated to 50-60 ° C, to obtain Epimedium extract, for subsequent use Take Angelica, add 10 times the amount of water and decoct 3 times, 2 hours each time, combine the decoction, filter, concentrate until the ratio of volume per milliliter to medicinal material per gram is 1:1, filte...

Embodiment 3

[0093] Recipe: 266g Aconite, 133g Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0094] Process: take Epimedium, add 10 times the amount of 80% ethanol solution to reflux extraction for 3 times, each time for 2 hours, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, and set aside; add 8 times the amount of water to extract the filter residue for 2 times , each time for 2 hours, filter, combine the filtrates, concentrate into a concentrated solution, combine with the above-mentioned alcohol extract, and concentrate to an extract with a relative density of 1.10-1.20 when concentrated to 50-60 ° C, to obtain Epimedium extract, for subsequent use Take Angelica, add 10 times the amount of water and decoct 3 times, 2 hours each time, combine the decoction, filter, concentrate until the ratio of volume per milliliter to medicinal material per gram is 1:1, filte...

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Abstract

The invention discloses a production process for a radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation. The preparation is mainly prepared from radix aconiti lateralis praeparata, radix aconiti preparata, cortex cinnamomi, radix codonopsis, Chinese angelica, parched white peony root, herba epimedii and stir-baked frankincense with vinegar. According to the production process disclosed by the invention, a specific production process and parameters of the radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation are improved according to the properties and effects of all the components in the formula of the radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation, so that the effective components in the herba epimedii can be easily detected, especially the icariin, and the detected content of the effective component icariin in the herba epimedii is high. A drug is more refined, the drug effect is more remarkable, and the clinical effect is good.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation process of Fugui Gutong preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex. It is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture in order to improve the efficacy of the medicine. [0003] Fugui Gutong is mainly made from Radix Aconite, Rhizoma Aconitum, Cinnamon, Codonopsis, Angelica, Stir-fried Paeoniae Alba, Epimedium and Vinegar Frankincense; For diseases such as hypertrophic arthritis of the cervical spine and knee joints caused by yang deficiency and cold dampness. [0004] In the prior art, Fugui Gutong is made in the following way: Cinnamon is crushed into fine powde...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P19/08A61P19/02
CPCA61K36/714A61K9/1623A61K9/1652A61K9/2059A61K36/232A61K36/296A61K36/324A61K36/344A61K36/54A61K36/65A61K36/71A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 韦卿游德仙吴鸿彭华曾海堃
Owner GUIZHOU HUAANTANG PHARMA CO LTD
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