Photoacoustic Quantitative Elasticity and Viscosity Dual-parameter Imaging Method and Device
An imaging method and imaging device technology, applied in the direction of measuring devices, material analysis through optical means, instruments, etc., can solve the problems of inability to distinguish between normal tissues and mutant tissues, and cannot realize dynamic process detection, etc., and achieve the benefits of industrialization promotion Effect
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Embodiment 1
[0047] Such as figure 1 As shown, the photoacoustic quantitative elastic and viscous dual-parameter imaging device of this embodiment includes a photoacoustic signal excitation component, a photoacoustic signal acquisition component, a photoacoustic signal processing component, and a detection and scanning component;
[0048] The photoacoustic signal excitation component includes a quasi-CW laser 1, a collimating lens 2 and a focusing lens 3; the wavelength of the laser emitted by the quasi-CW laser 1 is 1064nm, and the laser modulation frequency is 0-150KHz;
[0049] The photoacoustic signal acquisition component includes an ultrasonic probe 4, an ultrasonic coupling agent, a first signal amplifier 5, and a second signal amplifier 6; the ultrasonic probe 4 is a hollow probe, which can realize a reverse receiving mode and can Realize simultaneous measurement of rise time and phase difference;
[0050] The photoacoustic signal processing assembly includes an oscilloscope 7, a ...
Embodiment 2
[0061] The present embodiment is the experiment that utilizes agar sample to carry out, mainly comprises the following steps:
[0062] 1) The agar sample is made by mixing 0.75g, 1.00g, 1.25g, 1.50g of agar powder with 50mL of water, boiling and cooling, and the prepared concentration is 15g / L, 20g / L, 25g / L , 30g / L agar sample is fixed in the sample pool;
[0063] 2) The quasi-continuous laser emits laser pulses, which are collimated by the collimating lens and irradiated onto the sample to be tested through the focusing lens;
[0064] 3) The photoacoustic signal generated by the agar sample is received by the ultrasonic detector, and then amplified by the signal amplifier.
[0065] 4) The amplified photoacoustic signal is sent to the oscilloscope and the lock-in amplifier respectively, and this information is stored in the computer;
[0066] 5) by measuring rise time and phase difference, quantitative concentration is the elasticity, the viscosity of the agar sample of 15g / ...
Embodiment 3
[0068] This example is an experiment conducted using biological tissue samples.
[0069] A piece of biological tissue sample containing pork lean meat, pork fat, such as Figure 5 Shown; After the imaging method of embodiment 1, obtain the photoacoustic elastography image and the photoacoustic viscosity imaging image of biological tissue sample, respectively as Figure 6 and Figure 7 As shown, it can be seen that the method and device of the present invention can reconstruct the image of the difference distribution of elasticity and viscosity of the sample, and realize photoacoustic quantitative elasticity and viscosity imaging.
[0070] In summary, the present invention sends the amplified photoacoustic signal to the oscilloscope and lock-in amplifier respectively to obtain the rise time of the displacement and the phase difference of the photoacoustic signal, according to the relationship between the rise time of the displacement and the elasticity, and the photoacoustic s...
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Abstract
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