Opto-acoustic quantitative elasticity and viscosity double-parameter imaging method and device
An imaging method and imaging device technology, applied in the direction of measuring devices, material analysis through optical means, instruments, etc., can solve the problems of inability to distinguish between normal tissues and mutant tissues, and the inability to realize dynamic process detection, etc., and achieve the benefits of industrialization promotion Effect
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Embodiment 1
[0047] like figure 1 As shown, the photoacoustic quantitative elastic and viscous dual-parameter imaging device of this embodiment includes a photoacoustic signal excitation component, a photoacoustic signal acquisition component, a photoacoustic signal processing component, and a detection scanning component;
[0048] The photoacoustic signal excitation component includes a quasi-continuous laser 1, a collimating lens 2 and a focusing lens 3; the laser wavelength emitted by the quasi-continuous laser 1 is 1064 nm, and the laser modulation frequency is 0-150 KHz;
[0049] The photoacoustic signal acquisition assembly includes an ultrasonic detector 4, an ultrasonic couplant, a first signal amplifier 5 and a second signal amplifier 6; the ultrasonic detector 4 is a hollow detector, which can realize both the reverse receiving mode and the Realize simultaneous measurement of rise time and phase difference;
[0050] The photoacoustic signal processing component includes an oscil...
Embodiment 2
[0061] This embodiment is an experiment using agar samples, which mainly includes the following steps:
[0062] 1) The agar samples are obtained by mixing 0.75g, 1.00g, 1.25g, 1.50g of agar powder with 50mL of water, boiled and cooled, and the prepared concentration is 15g / L, 20g / L, 25g / L , 30g / L agar sample is fixed in the sample cell;
[0063] 2) The quasi-continuous laser emits laser pulses, which are collimated by the collimating lens and then irradiated on the sample to be tested through the focusing lens;
[0064] 3) The photoacoustic signal generated by the agar sample is received by the ultrasonic detector, and then amplified by the signal amplifier.
[0065] 4) The amplified photoacoustic signal is sent to the oscilloscope and the lock-in amplifier respectively, and the information is stored in the computer;
[0066] 5) By measuring the rise time and phase difference, quantify the elasticity and viscosity of agar samples with concentrations of 15g / L, 20g / L, 25g / L an...
Embodiment 3
[0068] This example is an experiment using biological tissue samples.
[0069] A piece of biological tissue sample containing pork lean meat, pork fat, such as Figure 5 After the imaging method in Example 1, the photoacoustic elastography and photoacoustic viscosity imaging of the biological tissue sample were obtained, as shown in Image 6 and Figure 7 As shown, it can be seen that the method and device of the present invention can reconstruct the image of the difference distribution of elasticity and viscosity of the sample, and realize photoacoustic quantitative elasticity and viscosity imaging.
[0070] To sum up, the present invention transmits the amplified photoacoustic signal to the oscilloscope and the lock-in amplifier respectively, so as to obtain the rise time of the displacement and the phase difference of the photoacoustic signal, according to the relationship between the rise time and elasticity of the displacement, and the photoacoustic signal. The relation...
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Abstract
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