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A nanopore gene detection sensor chip

A sensor chip and gene detection technology, applied in the direction of biochemical instruments, microbial measurement/inspection, bioreactor/fermenter combination, etc., can solve the problems of system measurement error and insufficient precision, achieve high precision, improve accuracy, The effect of shortening the detection time

Inactive Publication Date: 2018-10-23
南创咨询(北京)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the method proposed by Genia, since the circuit of the nanopore sensing unit realizes the linear conversion of current to voltage without amplification function, the system measurement error is caused due to insufficient precision

Method used

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  • A nanopore gene detection sensor chip
  • A nanopore gene detection sensor chip
  • A nanopore gene detection sensor chip

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Embodiment Construction

[0038] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0039] Such as Figure 6 It is a schematic diagram of the present invention, comprising n rows and m columns of sensing unit arrays, each column of sensing units sharing an operational amplifier bias circuit OPA, and a current-to-time-to-voltage conversion reading circuit (current-to-time-to- voltage conversion, C-TVC), analog-to-digital converter (ADC), and static random access memory (SRAM), such as the op amp bias circuit OPA in the first column is marked as : Operational amplifier bias circuit OPA c1 ; The current-time domain-voltage conversion reading circuit in the first column is marked as: current-time domain-voltage conversion reading circuit C-TVC c1 ; The analog-to-digital conversion circuit in the first column is marked as: Analog-to-digital conversion circuit ADC c1 ; The static random register bank in the first column is labeled: Static rando...

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Abstract

The invention discloses a nanopore gene detection sensor chip. The nanopore gene detection sensor chip comprises an operational amplifier (OPA) biasing circuit, an n-row m-column sensor unit 5T array, a row decoder, current-time domain-voltage conversion and reading circuits, analog-digital conversion (ADC) circuits, static random access memory (SRAM) sets and a column decoder. Sensor units 5T in the same row are processed through the corresponding current-time domain-voltage conversion and reading circuit and analog-digital conversion (ADC) circuit and static random access memory (SRAM) set and finally output under the control of the column decoder, the process is repeated till all the row sensor units are processed. By the adoption of the nanopore 5T sensing units compatible with the semiconductor technology and a C-TVC reading strategy for amplifying a sub-threshold, direct detection of a gene segment base pair of a 1pA nanopore current can be realized, the complexity of biological processing is reduced, the integration degree of the chip is further increased, and production cost of the chip is reduced.

Description

technical field [0001] The invention relates to a gene sequencing technology, in particular to a nanopore gene detection sensor chip. Background technique [0002] Gene sequencing is of revolutionary significance to life sciences, biotechnology and drug discovery. Such as figure 1 As shown, the first-generation sequencing technology was invented by Sanger in 1975, using the dideoxy chain termination method and fluorescence detection method, but this method is not only expensive but also takes a long time to test, and is not suitable for the detection of modern long gene sequences. Therefore, in order to further reduce the sequencing cost and shorten the sequencing time, the next-generation sequencing technology has evolved from the first-generation Sanger sequencing, to the second-generation pyrosequencing, and then to the third-generation Illumina's synthesis-by-side sequencing in recent years. Sequencing and Ion Torrent ion semiconductor sequencing, the cost of sequencin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/34
CPCC12Q1/6869C12Q2565/607C12Q2565/631
Inventor 姜钰刘旭余浩严媚
Owner 南创咨询(北京)有限公司