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Medicinal application of isocorydine derivative

A technology of isocydine and medicine, which is applied in the field of malate and its pharmaceutical application, can solve problems such as adverse reactions, unsatisfactory drug treatment effect, drug resistance, etc., and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2016-07-06
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the prevention and / or treatment of cervical cancer, these drugs are likely to cause multiple and severe adverse reactions, and some have developed drug resistance. still unsatisfactory

Method used

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  • Medicinal application of isocorydine derivative
  • Medicinal application of isocorydine derivative
  • Medicinal application of isocorydine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Isocorydine malate

[0048] 3.41 g (0.01 mol) of the compound isocydine and 1.34 g (0.01 mol) of malic acid were dissolved in 100 ml of boiling ethanol. The hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and stood for several hours in a temperature environment of 0-5°C to precipitate isorydine malate crystals, and the isorydine malate was filtered out. Salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 4.62 g of product.

Embodiment 2

[0050] Isocorydine malate

[0051] 3.41 g of the compound isocydine malate and 1.34 g of malic acid were stirred in 100 ml of refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, the crystals of isorydine malate are precipitated, and the crystals of isorydine malate are filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 4.61 g of product.

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Abstract

The invention relates to isocorydine malate or a pharmaceutically acceptable solvate thereof and an application of the compounds in preparation of medicines for preventing and / or treating cervical cancer.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to a malate of an isocydine derivative and a pharmaceutical use thereof. Background technique [0002] For now, although there are many kinds of drugs for the prevention and / or treatment of cervical cancer, these drugs are likely to cause multiple and severe adverse reactions, and some have developed drug resistance. Still unsatisfactory. Some active compounds for preventing and / or treating cervical cancer are described in the patent literature of China Invention Patent Granted Publication No. CN102302496B. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of...

Claims

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Application Information

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IPC IPC(8): C07D221/18C07C59/245C07C51/41A61K31/473A61P35/00
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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