Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of modernization of traditional Chinese medicine, can solve the problems of complex preparation method of Zhisou Dingchuan oral liquid, increase the difficulty of quality control, increase the difficulty of process optimization, and achieve stable and controllable quality, significant economic and social Benefit, bioavailability improvement effect

Inactive Publication Date: 2016-07-13
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The preparation method of Zhisou Dingchuan Oral Liquid is relatively complicated, and the pH value is adjusted twice, which increases the difficulty of quality control. Therefore, it is necessary to improve its preparation process in order to obtain the modernized Chinese medicine preparation of Zhisou Dingchuan Oral Liquid
However, many studies have found that after some traditional Chinese medicine compositions are refined by modern pharmaceutical technology, their curative effect is reduced to varying degrees compared with the original drug under the premise that the amount of crude drug remains unchanged.
The prescription of Zhisou Dingchuan Oral Liquid contains four medicinal materials, and there are many factors affecting the curative effect, which increases the difficulty of process optimization

Method used

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  • Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof
  • Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: preparation of Chinese medicine extract

[0022] 1. Prescription:

[0023] Ephedra 1000g Bitter almond 1000g Licorice 1000g Gypsum 1000g

[0024] Two. Preparation method:

[0025] Weigh each raw material according to the ratio of raw materials and set aside; crush bitter almonds into coarse powder, remove oil, add 8 times the amount of water to extract for 6 hours, collect volatile oil, and obtain volatile oil A; ephedra, gypsum, and licorice are extracted twice with water, Extract 10 times the amount for 2 hours, extract the second 8 times the amount for 1.5 hours, concentrate to a relative density of 1.25 at 50-60°C to obtain a concentrated solution B; dry the concentrated solution B to obtain a dry product I; combine the volatile oil A with the dried Mix the substance I to obtain the dry substance II; the dry substance II is the active ingredient of the medicine. The amount of active ingredient is 700 g.

Embodiment 2

[0026] Embodiment 2: preparation of Chinese medicine extract

[0027] 1. Prescription:

[0028] Ephedra 200g Bitter almond 200g Licorice 200g Gypsum 200g

[0029] Two. Preparation method:

[0030] Weigh each raw material according to the ratio of raw materials and set aside; crush bitter almonds into coarse powder, remove oil, add 6 times the amount of water and extract for 6 hours, collect volatile oil to obtain volatile oil A; extract ephedra, gypsum, and licorice twice with water Extract 8 times the amount for 2 hours, extract 6 times the amount for the second time for 2 hours, concentrate to a relative density of 1.30 at 50-60°C to obtain a concentrated solution B; dry the concentrated solution B to obtain a dry product I; combine the volatile oil A with the dried Mix the substance I to obtain the dry substance II; the dry substance II is the active ingredient of the medicine. The amount of active ingredient is 150 g.

Embodiment 3

[0031] Embodiment 3: preparation of Chinese medicine extract

[0032] 1. Prescription:

[0033] Ephedra 200g Bitter almond 200g Licorice 200g Gypsum 200g

[0034] Two. Preparation method:

[0035] Weigh each raw material according to the ratio of raw materials, and set aside; crush bitter almonds into coarse powder, remove oil, add 4 times the amount of water to extract for 8 hours, collect volatile oil, and obtain volatile oil A; extract ephedra, gypsum, and licorice once with water, and extract 12 times the amount Extract with water for 3 hours, concentrate to a relative density of 1.10 under the condition of 50-60°C to obtain the concentrated solution B; dry the concentrated solution B to obtain the dried product I; mix the volatile oil A with the dried product I to obtain the dried product II; dry product II , which is the active ingredient of the drug.

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Abstract

The invention discloses a traditional Chinese medicinal composition for suppressing cough and relieving asthma, and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. The traditional Chinese medicinal composition for suppressing cough and relieving asthma is prepared from Herbal Ephedrae and bitter apricot kernel. Compared with present commercial dosage forms, the composition disclosed in the invention has the advantages of stable and controllable quality, substantially improved curative effect, reduction of the taking dosage of patients, improved bioavailability, and substantial economic and social benefits.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for relieving cough and relieving asthma and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Zhisou Dingchuan Oral Liquid is a commercially available traditional Chinese medicine for relieving cough and relieving asthma. Its prescription is 1000g ephedra, 1000g bitter almond, 1000g licorice, and 1000g gypsum. The oral liquid has the functions of pungent and cool catharsis, clearing lung and relieving asthma. For external cold and internal heat, body heat and thirst, cough with excessive phlegm, shortness of breath, chest and diaphragm fullness; acute bronchitis with the above syndromes. [0003] The preparation method of Zhisou Dingchuan oral liquid is as follows: the above four flavors, except bitter almond, the other three flavors such as gypsum are decocted twice, each time for 1.5 hours, combined dec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P11/14A61P11/06A61K33/06
Inventor 王磊闫晓楠孙琳耿彤张宇王玉晶
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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