Compound licorice preparation for eliminating phlegm and relieving cough and preparation method thereof

A technology of compound licorice and preparations, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulas, etc., to achieve the effects of good taste, fast onset of action, and reasonable formula

Active Publication Date: 2015-03-25
FUZHOU NEPTUNUS FUYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Opioids are recessive drugs that can become addictive if taken over a long period of time or in high doses, even in low concentrations

Method used

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  • Compound licorice preparation for eliminating phlegm and relieving cough and preparation method thereof
  • Compound licorice preparation for eliminating phlegm and relieving cough and preparation method thereof
  • Compound licorice preparation for eliminating phlegm and relieving cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Licorice extract powder 450g, pentoxyverine citrate 3g, opium powder 14.08g, camphor 8g, star anise oil 8g, sodium benzoate 8g, sodium bicarbonate 378.13g, tartaric acid 343.76g, sodium carboxymethyl starch 57.29g, Lactose 171.88g, cross-linked polyvinylpyrrolidone 58.44g, polyethylene glycol 6000 66.46g, micropowder silica gel 45.83g, aspartame 13.32g, orange flavor 11.14g (licorice extract powder in the formula, citric acid spray Toverine, opium powder, camphor, and star anise oil are products prepared in accordance with the standards of the Chinese Pharmacopoeia 2010 edition, and are commercially available products; while sodium benzoate, sodium bicarbonate, tartaric acid, sodium carboxymethyl starch, lactose, and cross-linked polyethylene Pyrrolidone, polyethylene glycol 6000, micropowder silica gel, aspartame, and orange flavor essence are also commercially available pharmaceutical excipients. Other examples are the same as Example 1).

[0025] The preparation proc...

Embodiment 2

[0032] Licorice extract powder 450g, pentoxyverine citrate 3.35g, opium powder 13.85g, camphor 8g, star anise oil 8g, sodium benzoate 8g, sodium bicarbonate 501.02g, tartaric acid 442.08g, sodium carboxymethyl starch 76.63g , lactose 294.72g, cross-linked polyvinylpyrrolidone 79.57g, polyethylene glycol 6000 85.47g, micronized silica gel 44.26g, aspartame 15.8g, orange flavor 14.1g.

[0033] The preparation process comprises the following steps:

[0034] 1) Dissolve the above formula amount of camphor in the formula amount of star anise oil, and then add the camphor-dissolved star anise oil into the formula amount of micropowdered silica gel dried at 70°C with a water content of ≤1.5% and passed through a 80-mesh sieve. Stir and mix evenly, seal and place for 18 hours to obtain adsorbate powder.

[0035] 2) Same as Step 2 of Example 1.

[0036] 3). Same as Step 3 of Example 1.

[0037] 4) Dissolve polyethylene glycol 6000 with 75% (volume fraction) ethanol, then dissolve so...

Embodiment 3

[0040] Licorice extract powder 450g, pentoxyverine citrate 4.49g, opium powder 13.12g, camphor 8g, star anise oil 8g, sodium benzoate 8g, sodium bicarbonate 592.61g, tartaric acid 522.89g, sodium carboxymethyl starch 87.14g , lactose 278.81g, cross-linked polyvinylpyrrolidone 90.63g, polyethylene glycol 6000 78.43g, micronized silica gel 63.72g, aspartame 16.32g, orange flavor 12.66g.

[0041] The preparation process comprises the following steps:

[0042] 1) Dissolve the above formula amount of camphor in the formula amount of star anise oil, then add the camphor-dissolved star anise oil into the formula amount of micropowder silica gel dried at 70°C with a moisture content of ≤1.5% and pass through a 80 mesh sieve, and stir Mix evenly and seal for 16 hours to obtain adsorbate powder.

[0043] 2) Same as Step 2 of Example 1.

[0044] 3) Same as Step 3 of Example 1.

[0045] 4) Same as Step 4 of Example 2.

[0046] 5) Same as Step 5 of Example 1.

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Abstract

The invention discloses a compound licorice preparation for eliminating phlegm and relieving cough and a preparation method thereof. The compound licorice preparation is characterized in that each 1000 tablets of the compound licorice preparation comprise 450g of licorice extract powder, 5-2.11g of pentoxyverine citrate, 12.79-14.65g of opium powder, 8g of camphor, 8g of anise oil, and 8g of sodium benzoate; the tablet of the ompound licorice preparation has auxiliary material content of 80-65wt%; and the auxiliary materials comprise 30-36wt% of sodium bicarbonate, 25-31wt% of tartaric acid, 2-7wt% of sodium carboxymethyl starch, 10-25wt% of lactose, 2.5-7.5wt% of cross-linked polyvinylpyrrolidone, 3-8wt% of polyethylene glycol, 2-6.5wt% of aerosol, 0.3-4wt% of aspartame and 0.2-4wt% of orange-flavor essence. The compound licorice preparation has a reasonable formula, a good taste and high bioavailability, can produce effects fast, and can reduce a use amount of addiction opium powder.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a new composition and preparation of Compound Licorice Tablets, a medicine used for eliminating phlegm and relieving cough. Background technique [0002] The compound licorice tablets used for eliminating phlegm and relieving cough were successively recorded in "Chinese Pharmacopoeia" 1963, 1995, 2000, 2005, and 2010 editions. Its components are: licorice extract powder, opium powder, camphor, star anise oil, sodium benzoate ; Among them, licorice liquid extract is a protective antitussive expectorant; opium powder has a strong antitussive effect; camphor and star anise oil can stimulate the bronchial mucosa, reflexively increase the amount of sputum and make sputum easy to cough up; sodium benzoate is preservative. The above-mentioned ingredients form a compound preparation, which has the synergistic effect of relieving cough and eliminating phle...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61K9/20A61K47/36A61P11/10A61P11/14A61K31/125A61K31/216
Inventor 俞宁
Owner FUZHOU NEPTUNUS FUYAO PHARMA
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