Blank pipe fibroin microneedle drug administration system and preparation method thereof

Abstract

The invention belongs to the field of medical beauty microneedles and particularly relates to a blank pipe fibroin microneedle drug administration system and a preparation method thereof. The blank pipe fibroin microneedle drug administration system comprises a microneedle casing, a medicine, a swelling interlayer, a coating, a pressure-sensitive adhesive coating and a backing layer. The surface of the microneedle casing is provided with a plurality of evenly arranged needle-shaped protrusions, needle-shaped cavities are positioned in the needle-shaped protrusions, the volume of the needle-shaped protrusions accounts for 40-90% that of the needle-shaped protrusions, tips of the needle-shaped protrusions are provided with through holes, and the diameters of the through holes are 10-50 [mu]m. Medicines are placed in the needle-shaped cavities. The microneedle drug administration system is simple and short in manufacturing process, mild in processing condition, simple in finished product structure, flexible in medicine loading mode, higher in drug loading rate, suitable for symptoms needing quick drug release and high plasma concentration and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of medical cosmetic microneedles, and in particular relates to an empty tube silk fibroin microneedle drug delivery system and a preparation method thereof. Background technique [0002] With the development of micro-processing technology, a micro-needle technology that can pierce the epidermis without hurting the dermis and nerves came out more than ten years ago, bringing new ideas for transdermal drug delivery. At present, there are many technical bottlenecks in microneedle drug delivery technology, mainly including complex molding technology, high manufacturing cost, toxicity of microneedle materials, poor biocompatibility, easy to break and remain in the skin to cause allergic reactions, and inability to compare Precisely control the law of microneedle drug release, etc. [0003] Although traditional metal, glass, silicon and other solid microneedles have good penetration ability to change the skin permeability,...

AI Technical Summary

Problems solved by technology

The microneedle silk fibroin has a compact molecular structure, contains a large amount of Silk II crystals, and has a relatively large proportion of β-folded silk fibroin. Because the model drug is completely wrapped by the stable and dense silk fibroin, the release of the drug is slow, which is not conducive to certain Treatment of symptoms that require rapid onset of action and greater blood levels

Chinese invention patent (201510155449.X) describes a microneedle array with a swellable hollow silk fibroin microneedle shell. After the shell touches the body fluid and swells, the body fluid is introduced into the shell and contacted to dissolve the model drug, and t

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