cxcl13 DNA vaccine and its application

A DNA vaccine and vaccine technology, applied in the field of medicine, can solve the problems of human body toxicity and side effects, and achieve the effect of high potency
CN105797147BInactive Publication Date: 2019-06-25INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2019-06-25
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a CXCL13 (chemokine(C-X-C motif) ligand 13) DNA vaccine and an application thereof. According to the CXCL13 DNA vaccine, overall-length cDNA of CXCL13 and HBc (Hepatitis B core) are connected, and a vector is pcDNA 3.1(-). A tumor targeted drug prepared from the CXCL13 DNA vaccine generates stronger humoral immunity response by stimulating an active immunity system of an organism and can inhibit p-AKT, p-ERK and EMT signal pathways, thereby inhibiting tumor cell growth as well as invasion and metastasis and realizing the anti-tumor effect.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a CXCL13 (chemokine (C-X-C motif) ligand 13) cancer vaccine disclosed with functions of preventing and treating diseases. Background technique

[0002] Smoking and air pollution are major environmental health issues that my country and the world are facing. There are 1 billion smokers in the world, of which 350 million are in China; 1.59 million people die of lung cancer every year in the world, and 550,000 people die of lung cancer in my country, 90% of which are caused by smoking; air pollution causes 3.7 million premature deaths every year, Among them, there are 350,000 to 500,000 people in my country. Therefore, the prevention and treatment of lung and heart diseases caused by smoking and air pollution have become a major social demand in my country and the world.

[0003] Lung cancer has become the malignant tumor with the highest morbidity and mortality in the world. Ac...

Claims

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