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Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus

A 1H-19F-31P, nuclear magnetic resonance imaging technology, applied in the direction of using nuclear magnetic resonance imaging system for measurement, magnetic resonance measurement, measurement of magnetic variables, etc., can solve the problem of losing the best treatment time for tumors, and break the monopoly of medical technology. , improve the tumor cure rate, improve the effect of quality of life

Inactive Publication Date: 2016-08-10
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

[0003] However, traditional nuclear magnetic resonance technology can only provide anatomical image information, and the tumor can only be diagnosed when it develops to the middle and late stage, causing many cancer patients to lose the best time for tumor treatment

Method used

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Embodiment Construction

[0016] The following clearly and completely describes the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0017] The present invention uses the magnetic resonance pulse sequence 1H / 19F / 31P PANSY-COSY-3D fbSSFP to scan the desired imaging site, the reason being that 19F nucleus has the following advantages in NMR research:

[0018] (1) The spin quantum number of the 19F nucleus is 1 / 2, and its abundance in nature is 100%. The 19F nucleus has a high sensitivity in NMR, which is 83% of the sensitivity of 1H, and has a strong dipole weighing effect. , the protein topology and solvent exposure can be analyzed by measuring the distance betwee...

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Abstract

The invention discloses a multi-channel three-dimensional magnetic resonance imaging method based on the 1H-19F-31P nucleus. The method comprises the steps of scanning a part to be imaged by using a multi-channel phased-array coil and a magnetic resonance pulse sequence 1H / 19F / 31PPANSY-COSY-3D fbSSFP, and obtaining a plurality of phased-array coil images which are a 31P nucleus image, a 1H nucleus image and a 19F nucleus image respectively; and conducting registration and image fusion processing for the plurality of phased-array coil images and then obtaining a nuclear magnetic resonance image capable of providing tumor molecule information and metabolic information. The invention not only has a great practical significance in the early diagnosis of tumor, the improvement in the quality of life of patients, the improvement in the cure rate of tumor and the like, but also has a great strategic significance for our country to get rid of the shackles of foreign medical technology, break through the monopoly of foreign medical technology, and to occupy a world leading position in medical imaging, oncology and so forth.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance imaging method, in particular to a multi-channel three-dimensional nuclear magnetic resonance imaging method based on 1H-19F-31P atomic nuclei. Background technique [0002] At present, nuclear magnetic resonance (NMR) imaging technology has been widely used in medical diagnosis. NMR imaging is a biomagnetic nuclear spin imaging technology developed rapidly with the development of computer technology, electronic circuit technology, and superconductor technology. It uses a magnetic field and radio frequency pulses to resonate the precessing hydrogen nuclei (ie H+) in human tissue to generate radio frequency signals, which are then imaged by computer processing. Hydrogen nuclei are the nuclides of choice for human body imaging. Since various tissues of the human body contain a large amount of water and hydrocarbons, the nuclear magnetic resonance sensitivity of hydrogen nuclei is high and the signal i...

Claims

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Application Information

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IPC IPC(8): G01R33/56G01R33/561
CPCG01R33/5608G01R33/5615
Inventor 申宝忠
Owner HARBIN MEDICAL UNIVERSITY
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