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Application of apigenin in preparing medicines or health care foods for preventing and/or treating alcoholic liver injury

A technology of alcoholic liver injury and health food, which is applied in the field of biomedicine and can solve the problems of unreported inhibitory effect

Inactive Publication Date: 2016-09-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Apigenin (apigenin) is a common natural flavonoid monomer, which is widely found in various vegetables, fruits and some Chinese herbal medicines. Many scientific literatures have recorded that it has anti-tumor, anti-inflammatory, anti-oxidation and cardiovascular protection effects. , but there is no report on its inhibitory effect on CYP2E1 and its use in the prevention and treatment of alcoholic liver injury

Method used

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  • Application of apigenin in preparing medicines or health care foods for preventing and/or treating alcoholic liver injury
  • Application of apigenin in preparing medicines or health care foods for preventing and/or treating alcoholic liver injury
  • Application of apigenin in preparing medicines or health care foods for preventing and/or treating alcoholic liver injury

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1: the application of apigenin in the prevention and treatment of alcoholic liver injury.

[0022] 1. Test drug:

[0023] Apigenin, yellow-brown powder, purity >98%, provided by Suzhou Baozetang Pharmaceutical Technology Co., Ltd. Before use, use 0.5% sodium carboxymethylcellulose solution to prepare solutions with concentrations of 0.75% and 1.5%, respectively.

[0024] 2. Comparative test preparations:

[0025] Guladin (reduced glutathione sodium for injection), white freeze-dried block, produced by Pharminvest SPA in Italy, domestic repackaging company name: Kunming Jida Pharmaceutical Co., Ltd., product batch number: 2329, imported drug registration Certificate number: H20090005.

[0026] 3. Experimental materials:

[0027] 3.1 Animals:

[0028] Kunming mice, male, weighing 20-22 grams, clean grade, supplied by Shanghai Slack Experimental Animal Co., Ltd., experimental animal production license number: SCXK (Shanghai) 2012-0002, experimental animal u...

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PUM

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Abstract

The invention discloses an application of apigenin in preparing medicines or health care foods for preventing and / or treating alcoholic liver injury. On the basis of in vitro and in vivo pharmacological experiments, the apigenin (chemical name:5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) has an obvious protective effect on liver / hepatocyte injury induced by alcohol, and the main action mechanism of the apigenin is related to inhibition of CYP2E1 expression in liver / hepatocytes; and the apigenin, as a CYP2E1 inhibitor, can be used for preparing the medicines or the health care foods for preventing and / or treating the alcoholic liver injury; therefore, the apigenin has important scientific research and economic values.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and relates to the use of apigenin in preparing medicine or health food for preventing and / or treating alcoholic liver injury. Background technique [0002] Alcoholic liver damage is a liver disease caused by long-term or heavy drinking. The initial manifestation is fatty liver, which can develop into alcoholic hepatitis, liver fibrosis and cirrhosis. In severe cases, it can induce liver cancer and liver failure , has been listed as one of the leading causes of death due to liver disease in Western countries. In recent years, the incidence of alcoholic liver injury in my country has shown a significant increase. [0003] The main metabolic process of alcohol in the human body is as follows: figure 1 As shown, most of the ethanol is firstly metabolized into acetaldehyde through the action of alcohol dehydrogenase (ADH), and then metabolized into acetic acid under the catalysis of acetaldehyd...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/16A23L33/105
CPCA23V2002/00A61K31/352A23V2200/306A23V2250/2116
Inventor 谢梅林王峰薛洁朱增燕
Owner SUZHOU UNIV
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