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Use of sortilin as biomarker for affective/mood disorders

A technology for sorting proteins and uses in biological testing, biomaterial analysis, animal/human proteins, etc.

Inactive Publication Date: 2016-09-28
H LUNDBECK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the above has focused on bipolar disorder, the exact same challenges exist in diagnosing and treating unipolar depression

Method used

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  • Use of sortilin as biomarker for affective/mood disorders
  • Use of sortilin as biomarker for affective/mood disorders
  • Use of sortilin as biomarker for affective/mood disorders

Examples

Experimental program
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Embodiment Construction

[0018] Detailed Description of the Invention

[0019] The invention is based on the discovery that a level of sortilin at or below a predetermined value is associated with the presence of bipolar disorder and that a level of sortilin at or above a predetermined value is associated with the presence of unipolar depression . This discovery improves the diagnosis and treatment of bipolar disorder and unipolar depression.

[0020]It should be understood that the terms "diagnose", "diagnosed" or "diagnosing", as used in this application, are not intended to imply that the level of sortilin measured in a sample will only be Parameters used only when diagnosing subjects. Physicians will use several clinical observations in determining the correct diagnosis as outlined, for example, in ICD-10 and DSM-5. However, the present invention can assist in obtaining the correct diagnosis for a given subject.

[0021] The present invention therefore relates to the use of Sortilin or a fragm...

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PUM

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Abstract

The present invention relates to the use of Sortilin as a biomarker. In particular, Sortilin is useful as a biomarker for affective disorders. In one aspect of the invention Sortilin may be used to aid the diagnosing and to monitor disease progression in bipolar disorder and unipolar depression by measuring Sortilin levels. The invention further provides methods for informing the choice of treatment of bipolar disorder and unipolar depression by determining the levels of Sortilin.

Description

technical field [0001] The invention relates to the use of Sortilin as a biomarker. In particular, Sortilin is useful as a biomarker for affective disorders. In one aspect of the invention, sortilin can be used to diagnose, or to aid in diagnosis by measuring sortilin levels, and to monitor disease progression in bipolar disorder and unipolar depression. The present invention further provides methods for informing treatment options for bipolar disorder and unipolar depression by determining the level of sortilin. Background technique Background of the invention [0002] Bipolar disorder is a serious psychiatric condition which as a whole has a major negative impact on those patients, their relatives and society (Murray, C.J. 2012, Lancet 380, 2197-2223 ). The lifetime prevalence of bipolar disorder is approximately 1%-2% (Merikangas, K.R. 2011, Arch. Gen. Psychiatry. 68, 241-251), and the disease is among the leading causes of disability worldwide (Murray, C.J. 2012, L...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C07K14/705
CPCA61P25/24G01N33/6896G01N2800/304G01N2800/50G01N2800/52
Inventor J·L·耶普森A·尼科耶尔N·P·O·莫斯C·M·彼得森S·D·厄斯特高S·格莱若普
Owner H LUNDBECK AS
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