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Degradable magnetic nano material with caramel nanospheres as templates as well as preparation method and application of material in MRI (magnetic resonance imaging)

A technology of magnetic nano and nano materials, applied in chemical instruments and methods, preparations for in vivo experiments, pharmaceutical formulations, etc., can solve the problems of undiscovered ferromanganese contrast agents and other reports, and achieve high relaxation rate and particle size. Controllable, biocompatible effect

Inactive Publication Date: 2016-10-12
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] After searching, no report was found about ferromanganese-based contrast agents using caramel nanosphere nanosol as a template

Method used

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  • Degradable magnetic nano material with caramel nanospheres as templates as well as preparation method and application of material in MRI (magnetic resonance imaging)
  • Degradable magnetic nano material with caramel nanospheres as templates as well as preparation method and application of material in MRI (magnetic resonance imaging)
  • Degradable magnetic nano material with caramel nanospheres as templates as well as preparation method and application of material in MRI (magnetic resonance imaging)

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Embodiment Construction

[0010] The present invention is realized by adopting the following technical solutions:

[0011] A degradable magnetic nanomaterial using caramel nanospheres as a template, the magnetic nanomaterials are formed by modifying the surface of caramel nanospheres through manganese hypervalent compounds, iron salt compounds or manganese and iron salt compounds A magnetic nanomaterial, the magnetic nanomaterial uses caramel nanospheres as the inner core, and manganese oxide, iron oxide or manganese iron oxide is loaded on the surface of the caramel nanospheres to form a shell layer.

[0012] Preferably in the present invention, the particle diameter of the magnetic nanomaterial is 50-1000 nm, and the shell thickness is 10-100 nm.

[0013] Preferably in the present invention, the magnetic nanomaterials are caramel nanosphere-supported manganese oxide nanomaterials, caramel nanosphere-supported iron oxide nanomaterials, and caramel nanosphere-supported manganese-iron-oxygen nanomateria...

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Abstract

The invention relates to a degradable magnetic nano material with caramel nanospheres as templates. The magnetic nano material is formed by modifying surfaces of the caramel nanospheres with hypervalent compounds of manganese, salt compounds of iron or salt compounds of manganese and iron. According to the magnetic nano material, the caramel nanospheres are taken as inner cores, manganese oxides, iron oxides or manganese ferrite are supported on the surfaces of the caramel nanospheres, the preparation method is simple, and biomolecular glucose is taken as a raw material. The prepared nano material is applied in an MRI contrast agent, and the contrast agent has a good relaxation rate, low toxin, a large specific surface area, good biocompatibility and a good MRI effect, has a controllable particle size, can be used for preparation of sol spheres in the specification of 50-1,000 nm, can be applied to medical imaging and has potential clinical application value.

Description

technical field [0001] The invention relates to a degradable magnetic nanometer material using caramel nanospheres as a template, a preparation method thereof and an application in MRI, belonging to the technical field of inorganic nanometer materials. Background technique [0002] Magnetic resonance imaging (MRI) is one of the most important imaging techniques in modern medical clinical diagnosis, with the advantages of no radiation damage, high spatial and temporal resolution, and multi-plane imaging. Although magnetic resonance imaging has many advantages, one of the main problems faced by MRI is how to improve the contrast between lesions and normal tissues. Generally, contrast agents need to be added to make the imaging effect better, so as to achieve the purpose of accurate diagnosis. Magnetic resonance contrast agents are divided into positive contrast agents and negative contrast agents. 1 Brighten the signal of tissue in weighted imaging, such as complexes and nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/06C01G49/00C01G45/02A61K49/08A61K49/18
CPCC01G45/02A61K49/08A61K49/1827C01G49/0072C01G49/06C01P2004/04C01P2004/62C01P2004/64
Inventor 占金华郭卫华
Owner SHANDONG UNIV
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