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Nanometer titanium dioxide-loaded L-serine imprinted polymer thin layer plate and preparation method thereof

A technology of nano-titanium dioxide and imprinted polymers, applied in chemical instruments and methods, separation methods, other chemical processes, etc., can solve problems such as the inability to realize the resolution of serine chiral compounds, achieve enhanced molecular recognition performance, and improve surface imprinting effects Effect

Active Publication Date: 2016-10-12
湖北进创博生物科技有限公司
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Problems solved by technology

Conventional liquid chromatography stationary phase and thin layer chromatography are unable to achieve resolution of serine chiral compounds

Method used

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Embodiment Construction

[0014] The nano-titanium dioxide loaded L-serine imprinted polymer thin-layer plate and its preparation method are described in detail below.

[0015] (1) Pretreatment of nano-titanium dioxide: accurately weigh 6.0g nano-TiO 2 Bake at 353K for 12 hours, cool down, and measure the volume V 1 =20mL concentrated nitric acid solution, moved to a 100mL volumetric flask to prepare a nitric acid solution with a concentration of 3.2mol / L, and then the nano-TiO 2 After soaking in 3.2mol / L nitric acid solution for 12 hours, vacuum filter and wash the precipitate with deionized water to pH 7.0, and dry it in vacuum for 6 hours at 333K, and set aside;

[0016] (2) Surface modification of nano-titanium dioxide: weigh 2.0g of activated nano-TiO 2 , add 4 mL of γ-MAPS-methanol mixed solution [V / V, 1:1], react at 313K for 12 hours, cool, grind, wash with 50 mL of methanol and water to remove solids, dry, and set aside;

[0017] (3) Preparation of nano-titanium dioxide surface-grafted impri...

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Abstract

The invention provides a nanometer titanium dioxide-loaded L-serine imprinted polymer thin layer plate and a preparation method thereof. According to the invention, nanometer titanium dioxide is used as a carrier, L-serine is used as a template, and an L-serine molecularly imprinted polymer is prepared by using a surface imprinting method; the surface of titanium dioxide is activated by using a nitric acid solution, then gamma-MAPS is used for modifying activated titanium dioxide, so functional groups on the surface of a solid is improved, and the carrier has improved capability in surface grafting with the L-serine molecularly imprinted polymer; and then the thin layer plate is prepared from the obtained molecularly imprinted polymer, n-butanol-glacial acetic acid-water (V / V, 4: 1: 1) of ninhydrin with a concentration of 0.1% is used as a developing solvent, and when the developing solvent is used for separation of chiral compounds L-serine and D-serine, a relative Rf value is greater than 2.0, so L-serine and D-serine are separated. Thus, the problem that conventional thin-layer chromatography and conventional liquid chromatography cannot realize separation of a stationary phase is overcome, and separation of a molecularly imprinted thin layer of chiral amino acid compounds is realized. The invention provides a novel material and method for chiral resolution and compartment analysis of serine.

Description

technical field [0001] The invention relates to a thin-layer board loaded with L-serine imprinted polymer on the surface of nano-titanium dioxide and a preparation method thereof. Background technique [0002] Molecularly imprinted polymers (MIPs) are polymers synthesized by molecular imprinting technology that can specifically recognize and selectively adsorb specific target molecules (template molecules) and their structural analogs. MIP preparation principle: mix imprinted molecules (template molecules) with suitable functional monomers, and polymerize them with a cross-linking agent to form a three-dimensional cross-linked polymer network with a high degree of cross-linking around the imprinted molecules, and then The imprinted molecules are then removed by an appropriate method, and the final polymer obtained is a molecularly imprinted polymer. MIP has the properties of recognition, predetermined structure and activity, and practicability, so it has broad application p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L1/28C08L51/10C08J9/26C08F292/00C08F226/06C08F222/14B01J20/26B01J20/30B01D15/38
CPCB01D15/3852B01J20/06B01J20/268B01J2220/46C08F292/00C08J5/18C08J9/26C08J2301/28C08J2351/10C08J2451/10C08F222/14
Inventor 李辉张月王素素龚美叶龚梦婷
Owner 湖北进创博生物科技有限公司
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