Nano titanium dioxide loaded l-serine imprinted polymer thin layer plate and its preparation method

A nano-titanium dioxide, imprinted polymer technology, applied in chemical instruments and methods, separation methods, other chemical processes and other directions, can solve problems such as the inability to achieve serine chiral compound separation, and achieve enhanced molecular recognition performance and improved surface imprinting effect. Effect

Active Publication Date: 2018-10-02
湖北进创博生物科技有限公司
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AI Technical Summary

Problems solved by technology

Conventional liquid chromatography stationary phase and thin layer chromatography are unable to achieve resolution of serine chiral compounds

Method used

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Embodiment Construction

[0014] The nano-titania-supported L-serine imprinted polymer thin-layer plate and its preparation method will be described in detail below.

[0015] (1) Pretreatment of nano-TiO2: accurately weigh 6.0g nano-TiO 2 Bake for 12h at 353K, cool, and measure the volume V 1 =20mL of concentrated nitric acid solution, transferred to a 100mL volumetric flask to prepare a nitric acid solution with a concentration of 3.2mol / L, and then nano-TiO 2 After immersing in 3.2mol / L nitric acid solution for 12h, vacuum filter and wash the precipitate with deionized water to pH 7.0, vacuum dry for 6h at 333K temperature, standby;

[0016] (2) Surface modification of nano-TiO2: Weigh 2.0g of activated nano-TiO 2 , Add 4 mL of γ-MAPS-methanol mixed solution [V / V, 1:1], react at 313K for 12 hours, cool, grind, and wash with 50 mL methanol and water to remove solids, dry, and set aside;

[0017] (3) Preparation of grafted imprinted polymer on the surface of nanometer titanium dioxide: accurately weigh 400mg o...

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Abstract

The invention provides a nanometer titanium dioxide-loaded L-serine imprinted polymer thin layer plate and a preparation method thereof. According to the invention, nanometer titanium dioxide is used as a carrier, L-serine is used as a template, and an L-serine molecularly imprinted polymer is prepared by using a surface imprinting method; the surface of titanium dioxide is activated by using a nitric acid solution, then gamma-MAPS is used for modifying activated titanium dioxide, so functional groups on the surface of a solid is improved, and the carrier has improved capability in surface grafting with the L-serine molecularly imprinted polymer; and then the thin layer plate is prepared from the obtained molecularly imprinted polymer, n-butanol-glacial acetic acid-water (V / V, 4: 1: 1) of ninhydrin with a concentration of 0.1% is used as a developing solvent, and when the developing solvent is used for separation of chiral compounds L-serine and D-serine, a relative Rf value is greater than 2.0, so L-serine and D-serine are separated. Thus, the problem that conventional thin-layer chromatography and conventional liquid chromatography cannot realize separation of a stationary phase is overcome, and separation of a molecularly imprinted thin layer of chiral amino acid compounds is realized. The invention provides a novel material and method for chiral resolution and compartment analysis of serine.

Description

Technical field [0001] The invention relates to a thin-layer plate loaded with L-serine imprinted polymer on the surface of nano titanium dioxide and a preparation method thereof. Background technique [0002] Molecularly imprinted polymer (MIP) is a polymer synthesized by molecular imprinting technology that specifically recognizes and selectively adsorbs specific target molecules (template molecules) and their structural analogs. MIP preparation principle: mix imprinted molecules (template molecules) with suitable functional monomers, and polymerize them with a cross-linking agent to form a three-dimensional cross-linked polymer network with a high degree of cross-linking around the imprinted molecules, and then Then use an appropriate method to remove the imprinted molecules, and the final polymer is a molecularly imprinted polymer. MIP has the properties of recognition, structure-effect pre-determination, practicability, etc., so it has broad application prospects in many fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08L1/28C08L51/10C08J9/26C08F292/00C08F226/06C08F222/14B01J20/26B01J20/30B01D15/38
CPCB01D15/3852B01J20/06B01J20/268B01J2220/46C08F292/00C08J5/18C08J9/26C08J2301/28C08J2351/10C08J2451/10C08F222/14
Inventor 李辉张月王素素龚美叶龚梦婷
Owner 湖北进创博生物科技有限公司
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