Injection liquid for treating brain traumas and disturbance of consciousness after brain operation and preparation method of injection liquid

A technology of consciousness disturbance and injection, which is applied in the field of medicine, can solve problems such as the inability to eliminate air bubbles in time, carbonization of conglutinated liquid medicine, unqualified foreign matter, etc., and achieve the effects of avoiding conglutination, stable quality and simple process

Inactive Publication Date: 2016-11-09
邢涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] However, the inventor discovered in the actual production that during the filling process of the medicinal liquid, the medicinal liquid will generate a large number of air bubbles, and the air bubbles will hang on the filling needle and cannot be eliminated i

Method used

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  • Injection liquid for treating brain traumas and disturbance of consciousness after brain operation and preparation method of injection liquid
  • Injection liquid for treating brain traumas and disturbance of consciousness after brain operation and preparation method of injection liquid
  • Injection liquid for treating brain traumas and disturbance of consciousness after brain operation and preparation method of injection liquid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] prescription

[0037]

[0038] Preparation Process

[0039] Weigh the prescribed amount of cysteine ​​hydrochloride and disodium glycyrrhizinate, dissolve in an appropriate amount of water for injection, stir to dissolve, add the prescribed amount of Edaravone, stir to dissolve, adjust the pH value with a pH regulator, add the prescribed amount The methyl paraben and sodium chloride are stirred and dissolved, and the pH value is adjusted again with a pH value regulator. Check the finished product.

Embodiment 2

[0041] prescription

[0042]

[0043] Preparation process: with embodiment 1

Embodiment 3

[0045] prescription

[0046]

[0047] Preparation process: with embodiment 1

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Abstract

The invention belongs to the technical field of medicine and particularly relates to injection liquid for treating brain traumas and disturbance of consciousness after a brain operation and a preparation method of the injection liquid. The injection liquid is mainly prepared from active ingredients including edaravone, sodium chloride, cysteine hydrochloride, disodium glycyrrhizinate, methylparaben, a pH regulation agent and injection water. The prepared injection liquid is free of bubbles, adhesion of bubbles on an ampoule mouth is avoided, the phenomenon that visible foreign matter is not qualified due to carbonization of medicine liquid in the high-temperature sealing process is effectively avoided, the injection liquid is stable in mass and simple in process, and it is inspected through long-term experiments that all indexes meet specifications.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injection for treating traumatic brain injury and disturbance of consciousness after brain surgery and a preparation method thereof. Background technique [0002] Traumatic cerebral infarction (TCI) is one of the more serious complications of craniocerebral injury, especially the occurrence of large-scale infarction will aggravate the damage of brain function and seriously affect the prognosis of patients. For patients with craniocerebral injury, the symptoms and signs of cerebral infarction are masked by the symptoms of primary damage due to severe disturbance of consciousness, making early detection of TCI quite difficult. Cerebral infarction after craniocerebral injury often has an insidious onset, rapid progression, and is easily concealed by the symptoms of the primary injury. Especially in comatose patients, it is more difficult to find out, and treatment is...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4152A61K47/02A61K47/20A61K47/28A61K47/14A61P9/10A61P25/00
CPCA61K9/0019A61K9/08A61K31/4152A61K47/02A61K47/14A61K47/20A61K47/28
Inventor 邢涛
Owner 邢涛
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