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Application of an Eccentric Microsphere in Ultrasonic Controlled Release of Drugs

A microsphere and eccentric technology, which is applied in the direction of medical preparations, microcapsules, and pharmaceutical formulas of non-active ingredients, can solve the problems of focused ultrasound damage to the human body, limited use of ultrasonic controlled release, and low positioning control accuracy. Achieve the effects of improving drug utilization, precise positioning, and high drug effective concentration

Active Publication Date: 2019-10-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In current research, ultrasound-mediated drug carriers mainly include liposomes, micelles, microbubbles, etc., but there are still problems with the stability of these carriers, and most of them are irreversible in response to ultrasound. It is difficult to achieve the effect of sustained and controlled release, and the positioning control accuracy is not high; in terms of controlled release, most of the regulatory parameters used in current research are ultrasound intensity, but high-intensity focused ultrasound is harmful to the human body, which limits The scope of use of ultrasonic controlled release

Method used

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  • Application of an Eccentric Microsphere in Ultrasonic Controlled Release of Drugs
  • Application of an Eccentric Microsphere in Ultrasonic Controlled Release of Drugs
  • Application of an Eccentric Microsphere in Ultrasonic Controlled Release of Drugs

Examples

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Embodiment 1

[0029] Example 1 Preparation of polydimethylsiloxane eccentric microspheres with different resonance modes

[0030] attached figure 1 It is a schematic diagram of the preparation process of eccentric microspheres in the present invention. The preparation method of emulsified microspheres used in Example 1 is a microfluidic control preparation method, and the three-phase fluid control equipment used mainly includes two polyvinyl chloride tubes and two glass capillaries. The device is assembled by inserting a needle and a glass capillary into a polyvinyl chloride tube, and fixed with an epoxy adhesive to form a monolithic device.

[0031] The specific preparation process of polydimethylsiloxane eccentric microspheres comprises the following steps:

[0032] S1. Configure the microsphere shell material: Dilute the mixed polydimethylsiloxane (PDMS, components A and B, A:B=1:10) with dichloromethane, and the diluted mass ratio is PDMS:DCM= 3:1, mix well and remove air bubbles for ...

Embodiment 2

[0043] Example 2 Drug Release of Eccentric Microspheres at the Same Ultrasound Intensity and Different Ultrasonic Frequency

[0044] The specific process is as follows:

[0045] S1. Take the same amount of eccentric microspheres and put them into 3 identical serum bottles, add the same amount of pure water, close the lid tightly and confirm the seal;

[0046] S2. Prepare 3 identical water tanks, fill them with water and maintain the water temperature at 37°C;

[0047] S3. Three serums filled with eccentric microspheres were respectively fixed at the same position 2.5 cm below the water surface of each tank;

[0048] S4. Fix the three ultrasonic generator probes directly above the serum bottle and 0.5 cm below the water surface. The ultrasonic frequencies of the probes are 20 KHz, 25 KHz and 33 KHz respectively;

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Abstract

The invention provides application of eccentric microspheres to drug ultrasonic controlled release. The eccentric microspheres comprise shells and inner cores. The inner cores deviate from the centers of the eccentric microspheres, and a thin wall is formed on one side of each eccentric microsphere. The application has the following advantages that due to the fact that the eccentric microspheres have different resonant modes, drugs in the eccentric microsphere carriers can be precisely controlled to be slowly released or rapidly released through the resonance effect; due to the resonance effect of the eccentric microspheres, the release efficiency of the drugs in the eccentric microspheres is higher, the high drug effective concentration can be kept, and the drug utilization rate is increased; a preparation method is simple, positioning is precise, stability is high, and the eccentric microspheres are suitable for clinical application; the effective concentration of the drugs at focus positions can be kept within a long time, frequent drug delivery is not needed, and the application is an ideal means for real-time controllable targeted drug delivery.

Description

technical field [0001] The invention relates to the field of ultrasonic controlled release of medicines, in particular to the application of eccentric microspheres in ultrasonic controlled release of medicines. Background technique [0002] The treatment of most diseases is achieved by drug therapy, so it is very important to maintain the effective concentration of drugs at the lesion site for a long time without requiring frequent drug administration. According to the mechanism of drug release, the controlled release methods of drugs are mainly divided into material degradation controlled release mechanism and diffusion release mechanism. The influencing factors of material degradation controlled release include whether there are degrading enzymes, temperature and pH and other microchemical environments; diffusion release The mechanism is a physical process, which is mainly related to the stimulation of the external environment, such as electromagnetic, ultrasonic and light...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/34
Inventor 周建华唐均匀黄文威
Owner SUN YAT SEN UNIV