Combination of ginsenoside rb1 and rd and its application in the preparation of medicines for treating diseases related to photoreceptor cell death

A ginsenoside, photoreceptor technology, applied in sensory diseases, metabolic diseases, drug combinations, etc.

Active Publication Date: 2019-01-11
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing literature has not reported the combination of ginsenoside Rb1 and Rd in the treatment of diseases with photoreceptor cell death, retinal pigment epithelium and photoreceptor cell oxidative stress as the core pathology, including age-related macular degeneration, retinitis pigmentosa, Stargardt disease, etc. Pharmacological activity in retinal degenerative diseases such as cone-rod cell dystrophy and diabetic retinopathy

Method used

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  • Combination of ginsenoside rb1 and rd and its application in the preparation of medicines for treating diseases related to photoreceptor cell death
  • Combination of ginsenoside rb1 and rd and its application in the preparation of medicines for treating diseases related to photoreceptor cell death
  • Combination of ginsenoside rb1 and rd and its application in the preparation of medicines for treating diseases related to photoreceptor cell death

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Experimental program
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Effect test

Embodiment

[0043] In this example, through non-invasive retinal fundus tomography OCT technology, pathology, and immunohistochemistry research methods, the intervention effect of the combination of ginsenoside Rb1 and Rd on the mouse model of retinal light damage was clarified. The results of the study show that the combination of ginsenoside Rb1 and Rd can effectively interfere with the occurrence of photoreceptor cell death and retinal degeneration, and has a significant protective effect on the structure of the retina.

[0044] 1. Method

[0045] 1. Drugs

[0046] Ginsenoside Rb1 and Ginsenoside Rd. Ginsenoside Rb1 was purchased from Shanghai Yuanye Biotechnology Co., Ltd., 41753-43-9, Lot#H02J6X4, with a purity of ≥98%. Ginsenoside Rd was purchased from Shanghai Yuanye Biotechnology Co., Ltd., 52705-93-8, Lot#H02J6X2, with a purity of ≥98%.

[0047] 2. Animal model

[0048] 4-6 weeks old female Balb / c mice (slack, Shanghai) were used for the experiment. Mice were randomly divided into norm...

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Abstract

The invention relates to application of a ginsenoside Rb1 and Rd combination to preparation of a medicine for treating photoreceptor cell death related diseases. A mouse model suffering from retinal light damage is adopted to simulate the common key pathological links in the process of various degenerative retinal diseases so as to research the intervention effects of the ginsenoside Rb1 and Rd combination on the mouse model suffering from retinal light damage, and the results show that the medicinal combination can maintain the format of the retina outer nuclear layer, effectively prevent the retina outer nuclear layer from degenerative damage and thickness reduction, inhibit death of photoreceptor cells, block oxidative stress of retinal pigment epitheliums and photoreceptor cells, effectively inhibit retinal damage related immuno-inflammatory responses and remarkably improve the degenerative retinal diseases. Therefore, the ginsenoside Rb1 and Rd combination can be used for preparing the medicine for treating various degenerative retinal diseases including age-related macular degeneration, retinal pigment degeneration, Stargardt disease, cone-rod cell dystrophy, diabetic retinopathy and the like.

Description

Technical field [0001] The present invention relates to the field of medical technology, specifically, it relates to the preparation and treatment of ginsenoside Rb1 and Rd combination in the preparation and treatment of photoreceptor cell death, retinal pigment epithelial cells and photoreceptor cell oxidative stress, including age-related macular degeneration, Stargardt Diseases, cone-rod dystrophy, retinitis pigmentosa and diabetic retinopathy and other retinal degeneration drugs. Background technique [0002] Retinal degenerative diseases are a group of retinal photoreceptor cell oxidative stress, death and retinal pigment epithelial cell oxidative stress as the core pathological changes, which can cause visual impairment and even blindness, including age-related macular degeneration, Stargardt Disease, cone-rod dystrophy, retinitis pigmentosa, etc. In addition, excessive oxidative stress of photoreceptor cells is an important early pathological link of diabetic retinopathy....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P27/02A61P3/10A61P29/00A61P37/02
CPCA61K31/704A61K2300/00
Inventor 陈瑜张腾卞敏娟崔金刚王培伟于心同李黎杜宵烨丁李立强
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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